GenAge entry for SOD2 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 129)

HGNC symbol
SOD2 
Aliases
 
Common name
superoxide dismutase 2, mitochondrial 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

SOD2 is an antioxidant, the mitochondrial form of SOD and an important defence against oxidative damage. Evidence from invertebrates suggests it may play a role in ageing. Overexpression of SOD2 in flies significantly extends lifespan [1239]. Mice without SOD2 are not viable [658]. Reducing the activity of SOD2 in mice increases the levels of oxidative damage to DNA but does not affect lifespan [655]. SOD2 overexpression in mice slightly increases lifespan [1939], while gene deletion in connective tissue only resulted in mutant mice with a reduced lifespan and premature onset of aging-related phenotypes such as weight loss, skin atrophy, kyphosis, osteoporosis and muscle degeneration [1965]. Loss of SOD2 activity in the epidermis induces cellular senescence [4339]. In the long-lived alphaMUPA mice strain, a reduced level of SOD2 gene expression and activity is observed together with maintaining the capacity to produce high levels of SOD2 in response to the inflammatory stimulus [1561]. Exercise training elevates levels of SOD2 in aging mouse hearts. Overexpression of SOD2 in aging mouse hearts demonstrated a protective role against oxidative stress, fibrosis and apoptosis [4329]. Surprisingly, young mice with epidermal SOD2 deficiency have accelerated wound closure. In contrast, old mice with epidermal SOD2 deficiency show delayed wound closure, reduced epidermal thickness and epidermal stem cell exhaustion [4339].

Polymorphisms in the human SOD2 gene have been associated with type 2 diabetes [661] and cardiomyopathy [1693]. A longevity-associated polymorphism was observed for Ashkenazi males [1350], but not for Italian [2139] and Jordanian [2140] populations. Although it is possible that SOD2 plays a role in human ageing, further studies are needed to investigate this hypothesis.

Cytogenetic information

Cytogenetic band
6q25.3
Location
159,681,723 bp to 159,693,321 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000302; response to reactive oxygen species
GO:0000303; response to superoxide
GO:0001315; age-dependent response to reactive oxygen species
GO:0001836; release of cytochrome c from mitochondria
GO:0003069; vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure
GO:0006357; regulation of transcription from RNA polymerase II promoter
GO:0006801; superoxide metabolic process
GO:0008217; regulation of blood pressure
GO:0008285; negative regulation of cell proliferation
GO:0019430; removal of superoxide radicals
GO:0032364; oxygen homeostasis
And 5 more GO terms
Cellular component: GO:0005739; mitochondrion
GO:0005759; mitochondrial matrix
GO:0070062; extracellular exosome
Function: GO:0004784; superoxide dismutase activity
GO:0030145; manganese ion binding
GO:0042802; identical protein binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
CAT, SOD2, SOD1, APP, H2AFX, GPX4
STRING interaction network
Protein-Protein network diagram for SOD2

Retrieve sequences for SOD2

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
sod-3
Danio rerio
sod2
Drosophila melanogaster
Sod2
Mus musculus
Sod2
Rattus norvegicus
Sod2
Saccharomyces cerevisiae
SOD2
Schizosaccharomyces pombe
SPBC16A3.14

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as SOD2
  • A homolog of this gene for Drosophila melanogaster is present as Sod2
  • A homolog of this gene for Mus musculus is present as Sod2
GenDR gene manipulations
  • A homolog of this gene for Saccharomyces cerevisiae is present as SOD2
LongevityMap
  • This gene is present as SOD2

Selected references

External links

EPD
HS_SOD2
ORF Accession
NM_000636
CDS Accession
NP_000627
OMIM
147460
HPRD
00938
Ensembl
SOD2
UniProt/Swiss-Prot
SODM_HUMAN
GeneCards
SOD2
Entrez Gene
6648
UniGene
487046
GenAtlas
SOD2
Internet
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