Mus musculusGenAge entry for Sod2 (Mus musculus)

Gene information (ID: 827)

Symbol
Sod2
Aliases
MnSOD; Sod-2
Name
Superoxide dismutase 2, mitochondrial
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
Gene deletion in connective tissue resulted in mutant mice with a reduced lifespan and premature onset of aging-related phenotypes such as weight loss, skin atrophy, kyphosis, osteoporosis and muscle degeneration.
% change in max lifespan
Maximum lifespan is 14% lower.
% change in avg or median lifespan
Median lifespan is 43% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Deletion in connective tissue
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as SOD2
    • A homolog of this gene for Drosophila melanogaster is present as Sod2
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as SOD2
    GenDR gene manipulations
    • A homolog of this gene for Saccharomyces cerevisiae is present as SOD2
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as SOD2

    Homologs in other organisms

    Caenorhabditis elegans
    sod-3
    Danio rerio
    sod2
    Drosophila melanogaster
    Sod2
    Homo sapiens
    SOD2
    Rattus norvegicus
    Sod2
    Saccharomyces cerevisiae
    SOD2
    Schizosaccharomyces pombe
    SPBC16A3.14

    External links

    Mouse Genome Informatics
    Search
    Ensembl
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    Entrez Gene
    View on Entrez Gene database (20656)
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar