Drosophila melanogasterGenAge entry for Sod2 (Drosophila melanogaster)

Gene information (ID: 624)

Symbol
Sod2
Aliases
CG8905; Dmel\CG8905; dSOD2; Mito; SOD; mitSOD2; Mn; SOD; M
Name
Superoxide dismutase 2 (Mn)
Organism
Drosophila melanogaster (AnAge)
Known functions and activities
Protects cells against oxygen toxicity

Potential relevance to longevity and/or ageing

Observations
RNA interference results in increased oxidative stress and early-onset mortality in young adults.
Lifespan Effect
Decrease
Genetic Manipulation
RNA interference
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Gene overexpression resulted in a 20% increase in mean and maximal lifespan.
    % change in max lifespan
    Maximum lifespan is 20% higher.
    % change in avg or median lifespan
    Average lifespan is 20% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Overexpression
    Longevity Category
    Pro-Longevity
    Primary reference

      In other databases

      GenAge model organism genes
      • A homolog of this gene for Saccharomyces cerevisiae is present as SOD2
      • A homolog of this gene for Mus musculus is present as Sod2
      GenAge human genes
      • A homolog of this gene for Homo sapiens is present as SOD2
      GenDR gene manipulations
      • A homolog of this gene for Saccharomyces cerevisiae is present as SOD2
      LongevityMap
      • A homolog of this gene for Homo sapiens is present as SOD2

      Homologs in other organisms

      Caenorhabditis elegans
      sod-3
      Danio rerio
      sod2
      Homo sapiens
      SOD2
      Mus musculus
      Sod2
      Rattus norvegicus
      Sod2
      Saccharomyces cerevisiae
      SOD2
      Schizosaccharomyces pombe
      SPBC16A3.14

      External links

      FlyBase
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (36878)
      Homologues
      Search HomoloGene
      UniProt
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      Internet
      Search Google or Search Google Scholar