GenAge entry for HIF1A (Homo sapiens)

Gene name (HAGRID: 65)

HGNC symbol
HIF1A 
Aliases
MOP1; HIF-1alpha; PASD8; HIF1; bHLHe78 
Common name
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

HIF1A is a transcription factor that responds to oxidative stress and oxygen [435]. Changes in HIF1A with age have been reported in rats and could be related to age-related pathologies [1593], such as neurodegeneration [1534]. Deficiencies in HIF1A have not been associated with ageing in mice [434]. Further evidence is needed to directly link HIF1A to human ageing.

Cytogenetic information

Cytogenetic band
14q23.2
Location
61,695,401 bp to 61,748,259 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001525; angiogenesis
GO:0001666; response to hypoxia
GO:0001755; neural crest cell migration
GO:0001837; epithelial to mesenchymal transition
GO:0001892; embryonic placenta development
GO:0001922; B-1 B cell homeostasis
GO:0001938; positive regulation of endothelial cell proliferation
GO:0001947; heart looping
GO:0002052; positive regulation of neuroblast proliferation
GO:0002248; connective tissue replacement involved in inflammatory response wound healing
GO:0003151; outflow tract morphogenesis
And 63 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0016607; nuclear speck
GO:0031514; motile cilium
GO:0090575; RNA polymerase II transcription factor complex
GO:1904115; axon cytoplasm
Function: GO:0000989; transcription factor activity, transcription factor binding
GO:0001076; transcription factor activity, RNA polymerase II transcription factor binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001228; transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003705; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0019899; enzyme binding
GO:0019901; protein kinase binding
GO:0031625; ubiquitin protein ligase binding
And 8 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SHC1, TP53, ATM, STAT3, HDAC3, MYC, PARP1, BRCA1, CREBBP, BCL2, VCP, HSP90AA1, UBE2I, EP300, RB1, RELA, HDAC1, SP1, JUN, APEX1, HSPA8, SIN3A, HDAC2, MAX, MDM2, ESR1, CTNNB1, CDKN2A, STUB1, ARNTL, SQSTM1
STRING interaction network
Protein-Protein network diagram for HIF1A

Retrieve sequences for HIF1A

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
hif-1
Danio rerio
hif1ab
Danio rerio
hif1aa
Drosophila melanogaster
sima
Mus musculus
Hif1a
Rattus norvegicus
Hif1a

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as hif-1
GenDR gene manipulations
  • A homolog of this gene for Caenorhabditis elegans is present as hif-1
LongevityMap
  • This gene is present as HIF1A
CellAge
  • This gene is present as HIF1A

Selected references

External links

EPD
HS_HIF1A
ORF Accession
NM_001530
CDS Accession
NP_001521
OMIM
603348
HPRD
04517
Ensembl
HIF1A
UniProt/Swiss-Prot
HIF1A_HUMAN
GeneCards
HIF1A
Entrez Gene
3091
GenAtlas
HIF1A
Internet
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