GenAge entry for HIF1A (Homo sapiens)
Gene name (HAGRID: 65)
- HGNC symbol
- HIF1A
- Aliases
- MOP1; HIF-1alpha; PASD8; HIF1; bHLHe78
- Common name
- hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
- Description
HIF1A is a transcription factor that responds to oxidative stress and oxygen [435]. Changes in HIF1A with age have been reported in rats and could be related to age-related pathologies [1593], such as neurodegeneration [1534]. Deficiencies in HIF1A have not been associated with ageing in mice [434]. Further evidence is needed to directly link HIF1A to human ageing.
Cytogenetic information
- Cytogenetic band
- 14q23.2
- Location
- 61,695,401 bp to 61,748,259 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0001525; angiogenesis
GO:0001666; response to hypoxia
GO:0001755; neural crest cell migration
GO:0001837; epithelial to mesenchymal transition
GO:0001892; embryonic placenta development
GO:0001922; B-1 B cell homeostasis
GO:0001938; positive regulation of endothelial cell proliferation
GO:0001947; heart looping
GO:0002052; positive regulation of neuroblast proliferation
GO:0002248; connective tissue replacement involved in inflammatory response wound healing
GO:0003151; outflow tract morphogenesis
And 63 more GO terms Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0016607; nuclear speck
GO:0031514; motile cilium
GO:0090575; RNA polymerase II transcription factor complex
GO:1904115; axon cytoplasm
Function: GO:0000989; transcription factor activity, transcription factor binding
GO:0001076; transcription factor activity, RNA polymerase II transcription factor binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001228; transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003705; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0019899; enzyme binding
GO:0019901; protein kinase binding
GO:0031625; ubiquitin protein ligase binding
And 8 more GO terms
Protein interactions and network
- Protein-protein interacting partners in GenAge
- SHC1, TP53, ATM, STAT3, HDAC3, MYC, PARP1, BRCA1, CREBBP, BCL2, VCP, HSP90AA1, UBE2I, EP300, RB1, RELA, HDAC1, SP1, JUN, APEX1, HSPA8, SIN3A, HDAC2, MAX, MDM2, ESR1, CTNNB1, CDKN2A, STUB1, ARNTL, SQSTM1
- STRING interaction network
Retrieve sequences for HIF1A
Homologs in model organisms
- Caenorhabditis elegans
- hif-1
- Danio rerio
- hif1ab
- Danio rerio
- hif1aa
- Drosophila melanogaster
- sima
- Mus musculus
- Hif1a
- Rattus norvegicus
- Hif1a
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as hif-1
- GenDR gene manipulations
- A homolog of this gene for Caenorhabditis elegans is present as hif-1
- LongevityMap
- This gene is present as HIF1A
- CellAge
- This gene is present as HIF1A