- Symbol
- hif-1
- Name
- HIF (Hypoxia Inducible Factor) homologa
- Organism
- Caenorhabditis elegans (AnAge)
- Observations
- Transgenic overexpression of HIF-1 extends lifespan by 12-34% depending on the level of over-expression.
- % change in avg or median lifespan
- Mean lifespan is up to 34% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Deletion of HIF-1 (ia04) extends mean lifespan by 24%. Maximum lifespan is also extended.
- % change in avg or median lifespan
- Mean lifespan is 24% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Mutation
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Observations
- Deletion of HIF-1 through a null-allele mutation (ia4) is not sufficient to significantly influence lifespan
- Lifespan Effect
- Not Recorded
- Genetic Manipulation
- Mutation
- Primary reference
-
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as HIF1A
- GenDR gene manipulations
- This gene is present as hif-1
- LongevityMap
- A homolog of this gene for Homo sapiens is present as HIF1A
- CellAge
- A homolog of this gene for Homo sapiens is present as EPAS1
- A homolog of this gene for Homo sapiens is present as HIF1A
- CellAge gene expression
- A homolog of this gene for Homo sapiens is present as EPAS1
- Danio rerio
- hif1al2
- Danio rerio
- hif1al
- Danio rerio
- hif1ab
- Danio rerio
- epas1b
- Danio rerio
- hif1aa
- Danio rerio
- epas1a
- Drosophila melanogaster
- sima
- Homo sapiens
- HIF1A
- Homo sapiens
- HIF3A
- Homo sapiens
- EPAS1
- Mus musculus
- Hif3a
- Mus musculus
- Epas1
- Mus musculus
- Hif1a
- Rattus norvegicus
- Epas1
- Rattus norvegicus
- Hif1a
- Rattus norvegicus
- Hif3a
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (180359)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for hif-1 (Caenorhabditis elegans)