Cell Senescence Entries for STAT5A

Cell Types
Fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockout, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Mallette et al. (2008) Myc down-regulation as a mechanism to activate the Rb pathway in STAT5A-induced senescence. J Biol Chem 282(48)34938-44 (PubMed)

STAT5A Gene Information

HGNC symbol
STAT5A 
Aliases
MGF; STAT5 
Common name
signal transducer and activator of transcription 5A 
Entrez Id
6776
Description
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013].

STAT5A Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:7165; signal transduction
GO:19221; cytokine-mediated signaling pathway
GO:6357; regulation of transcription by RNA polymerase II
GO:60397; growth hormone receptor signaling pathway via JAK-STAT
GO:6952; defense response
GO:42127; regulation of cell population proliferation
GO:1938; positive regulation of endothelial cell proliferation
GO:7259; receptor signaling pathway via JAK-STAT
GO:7595; lactation
GO:43536; positive regulation of blood vessel endothelial cell migration
And 7 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:785; chromatin
GO:90575; RNA polymerase II transcription regulator complex
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
Show all GO terms

Homologs of STAT5A in Model Organisms

Caenorhabditis elegans
sta-1
Danio rerio
stat5a
Danio rerio
stat5b
Drosophila melanogaster
Stat92E
Mus musculus
Stat5a
Rattus norvegicus
Stat5a

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as Stat92E
GenAge human genes
  • This gene is present as STAT5A

External links

OMIM
601511
Ensembl
ENSG00000126561
Entrez Gene
6776
UniGene
437058
1000 Genomes
1000 Genomes
HPRD
GenAtlas
STAT5A
GeneCards
STAT5A