Cell Senescence Entries for STAT5A
- Cell Types
- Fibroblast
- Cell Lines
- Primary cell
- Cancer Cell?
- No
- Method
- Knockout, Overexpression
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Induces
- Primary Reference
- Mallette et al. (2008) Myc down-regulation as a mechanism to activate the Rb pathway in STAT5A-induced senescence. J Biol Chem 282(48)34938-44 (PubMed)
STAT5A Gene Information
- HGNC symbol
- STAT5A
- Aliases
- MGF; STAT5
- Common name
- signal transducer and activator of transcription 5A
- Entrez Id
- 6776
- Description
- The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013].
STAT5A Ontologies
- Gene Ontology
-
Process: GO:6355; regulation of transcription, DNA-templated
GO:7165; signal transduction
GO:19221; cytokine-mediated signaling pathway
GO:6357; regulation of transcription by RNA polymerase II
GO:60397; growth hormone receptor signaling pathway via JAK-STAT
GO:6952; defense response
GO:42127; regulation of cell population proliferation
GO:1938; positive regulation of endothelial cell proliferation
GO:7259; receptor signaling pathway via JAK-STAT
GO:7595; lactation
GO:43536; positive regulation of blood vessel endothelial cell migration
And 7 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:785; chromatin
GO:90575; RNA polymerase II transcription regulator complex
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
Homologs of STAT5A in Model Organisms
- Caenorhabditis elegans
- sta-1
- Danio rerio
- stat5a
- Danio rerio
- stat5b
- Drosophila melanogaster
- Stat92E
- Mus musculus
- Stat5a
- Rattus norvegicus
- Stat5a
In other databases
- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as Stat92E
- GenAge human genes
- This gene is present as STAT5A
External links
- OMIM
- 601511
- Ensembl
- ENSG00000126561
- Entrez Gene
- 6776
- UniGene
- 437058
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- STAT5A
- GeneCards
- STAT5A