Saccharomyces cerevisiaeGenAge entry for RAS2 (Saccharomyces cerevisiae)

Gene information (ID: 540)

Symbol
RAS2
Aliases
CTN5; CYR3; GLC5; TSL7
Name
GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous gr
Organism
Saccharomyces cerevisiae (AnAge)

Potential relevance to longevity and/or ageing

Observations
Overexpression of a mutant gene caused a 43% increase in mean and 18% increase in maximum lifespan.
% change in max lifespan
Maximum lifespan is 18% higher.
% change in avg or median lifespan
Average lifespan is 43% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Deletion of the RAS2 gene, which functions upstream of CYR1, doubles the mean life span by a mechanism that requires Msn2/4 and Sod2
    Lifespan Effect
    Increase
    Genetic Manipulation
    Deletion
    Longevity Category
    Anti-Longevity
    Primary reference

      In other databases

      GenAge model organism genes
      • A homolog of this gene for Caenorhabditis elegans is present as let-60

      Homologs in other organisms

      Caenorhabditis elegans
      let-60
      Danio rerio
      nras
      Drosophila melanogaster
      Ras85D
      Homo sapiens
      RRAS
      Mus musculus
      Rras
      Rattus norvegicus
      Rras

      External links

      Saccharomyces Genome Database
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (855625)
      Homologues
      Search HomoloGene
      UniProt
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      Internet
      Search Google or Search Google Scholar