Cell Senescence Entries for HRAS

Cell Types
Lung fibroblast
Cell Lines
IMR-90, WI-38
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Promotes
Observations
Expression of oncogenic ras (HRAS) in lung fibroblasts resulted in a permanent G1 arrest, accompanied by accumulation of senescence associated factors, p53 and p16. These changes were phenotypically indistinguishable from cellular senescence.
Primary Reference

    HRAS Gene Information

    HGNC symbol
    HRAS 
    Aliases
    CTLO; HAMSV; HRAS1; RASH1; p21ras; C-H-RAS; H-RASIDX; C-BAS/HAS; C-HA-RAS1 
    Common name
    HRas proto-oncogene, GTPase 
    Entrez Id
    3265
    Description
    This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]

    HRAS Ontologies

    Gene Ontology
    Process: GO:38128; ERBB2 signaling pathway
    GO:38095; Fc-epsilon receptor signaling pathway
    GO:165; MAPK cascade
    GO:7265; Ras protein signal transduction
    GO:50852; T cell receptor signaling pathway
    GO:42088; T-helper 1 type immune response
    GO:9887; animal organ morphogenesis
    GO:7411; axon guidance
    GO:7050; cell cycle arrest
    GO:8283; cell proliferation
    GO:7166; cell surface receptor signaling pathway
    And 37 more GO terms
    Cellular component: GO:5794; Golgi apparatus
    GO:139; Golgi membrane
    GO:5737; cytoplasm
    GO:5829; cytosol
    GO:5634; nucleus
    GO:48471; perinuclear region of cytoplasm
    GO:5886; plasma membrane
    Function: GO:19003; GDP binding
    GO:5525; GTP binding
    GO:3924; GTPase activity
    GO:8022; protein C-terminus binding
    GO:5515; protein binding
    Show all GO terms

    Homologs of HRAS in Model Organisms

    Danio rerio
    hrasb
    Mus musculus
    Hras1
    Rattus norvegicus
    Hras1

    In other databases

    GenAge human genes
    • This gene is present as HRAS
    LongevityMap
    • This gene is present as HRAS

    External links

    OMIM
    190020
    Ensembl
    ENSG00000174775
    Entrez Gene
    3265
    UniGene
    37003
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    HRAS
    GeneCards
    HRAS