Cell Senescence Entries for PRKCD
- Cell Types
- Lung fibroblast
- Cell Lines
- TIG-1
- Cancer Cell?
- No
- Method
- Knockdown, Overexpression
- Type of senescence
- Replicative
- Senescence Effect
- Induces
- Primary Reference
- Katakura et al. (2009) Protein kinase C delta plays a key role in cellular senescence programs of human normal diploid cells. J Biochem 146(1)87-93 (PubMed)
PRKCD Gene Information
- HGNC symbol
- PRKCD
- Aliases
- Common name
- protein kinase C delta
- Entrez Id
- 5580
- Description
- The protein encoded by this gene is a member of the protein kinase C family of serine- and threonine-specific protein kinases. The encoded protein is activated by diacylglycerol and is both a tumor suppressor and a positive regulator of cell cycle progression. Also, this protein can positively or negatively regulate apoptosis. Defects in this gene are a cause of autoimmune lymphoproliferative syndrome. [provided by RefSeq, Aug 2017].
PRKCD Ontologies
- Gene Ontology
-
Process: GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:6915; apoptotic process
GO:18108; peptidyl-tyrosine phosphorylation
GO:2000303; regulation of ceramide biosynthetic process
GO:80090; regulation of primary metabolic process
GO:18105; peptidyl-serine phosphorylation
GO:42742; defense response to bacterium
GO:35556; intracellular signal transduction
GO:50821; protein stabilization
And 39 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5783; endoplasmic reticulum
GO:5829; cytosol
GO:5886; plasma membrane
GO:5739; mitochondrion
GO:12505; endomembrane system
GO:48471; perinuclear region of cytoplasm
GO:5576; extracellular region
GO:5654; nucleoplasm
And 6 more GO terms
Show all GO termsFunction: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:4713; protein tyrosine kinase activity
GO:5515; protein binding
And 10 more GO terms
Homologs of PRKCD in Model Organisms
- Caenorhabditis elegans
- tpa-1
- Danio rerio
- prkcda
- Danio rerio
- prkcdb
- Drosophila melanogaster
- Pkcdelta
- Mus musculus
- Prkcd
- Rattus norvegicus
- Prkcd
- Saccharomyces cerevisiae
- PKC1
- Schizosaccharomyces pombe
- pck1
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as tpa-1
- GenAge human genes
- This gene is present as PRKCD
External links
- OMIM
- 176977
- Ensembl
- ENSG00000163932
- Entrez Gene
- 5580
- UniGene
- 155342
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- PRKCD
- GeneCards
- PRKCD