GenAge entry for PTPN1 (Homo sapiens)

Gene name (HAGRID: 33)

HGNC symbol: PTPN1
Aliases: PTP1B
Common name: protein tyrosine phosphatase, non-receptor type 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description: PTPN1 inhibits insulin (INS) signalling and plays a role in INS sensitivity and fuel metabolism. Mice lacking PTPN1 are protected from diet-induced obesity and have enhanced enhanced INS sensitivity [323]. PTP1B negatively regulates leptin (LEP) signalling [1912]. PTPN1 may thus be related to certain age-associated pathologies such as obesity.

Cytogenetic information

Cytogenetic band: 20q13.1-q1
Location: 50,510,321 bp to 50,584,762 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0006470; protein dephosphorylation
GO:0006987; activation of signaling protein activity involved in unfolded protein response
GO:0007257; activation of JUN kinase activity
GO:0008286; insulin receptor signaling pathway
GO:0009966; regulation of signal transduction
GO:0009968; negative regulation of signal transduction
GO:0030100; regulation of endocytosis
GO:0030948; negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0030968; endoplasmic reticulum unfolded protein response
GO:0031532; actin cytoskeleton reorganization
GO:0033157; regulation of intracellular protein transport
GO:0035335; peptidyl-tyrosine dephosphorylation
GO:0035791; platelet-derived growth factor receptor-beta signaling pathway
GO:0036498; IRE1-mediated unfolded protein response
GO:0043407; negative regulation of MAP kinase activity
GO:0046627; negative regulation of insulin receptor signaling pathway
GO:0060338; regulation of type I interferon-mediated signaling pathway
GO:0060397; JAK-STAT cascade involved in growth hormone signaling pathway
GO:0061098; positive regulation of protein tyrosine kinase activity
GO:0070373; negative regulation of ERK1 and ERK2 cascade
GO:0098609; cell-cell adhesion
GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway
GO:1902236; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1903896; positive regulation of IRE1-mediated unfolded protein response
GO:1903898; negative regulation of PERK-mediated unfolded protein response
GO:1990264; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
GO:2000646; positive regulation of receptor catabolic process

Cellular component:

GO:0005769; early endosome
GO:0005783; endoplasmic reticulum
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005913; cell-cell adherens junction
GO:0097443; sorting endosome
GO:0098554; cytoplasmic side of endoplasmic reticulum membrane

Function:

GO:0004725; protein tyrosine phosphatase activity
GO:0005158; insulin receptor binding
GO:0005515; protein binding
GO:0008270; zinc ion binding
GO:0019899; enzyme binding
GO:0019901; protein kinase binding
GO:0030971; receptor tyrosine kinase binding
GO:0044822; poly(A) RNA binding
GO:0046875; ephrin receptor binding
GO:0051721; protein phosphatase 2A binding
GO:0098641; cadherin binding involved in cell-cell adhesion

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: GHR, IGF1R, STAT5B, STAT3, STAT5A, IRS1, EGFR, INSR, GSK3B, GRB2, ATF2, JAK2, CTNNB1, ZMPSTE24
STRING interaction network

Retrieve sequences for PTPN1

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: ptpn1
Drosophila melanogaster: Ptp61F
Mus musculus: Ptpn1
Rattus norvegicus: Ptpn1
Saccharomyces cerevisiae: PTP1

In other databases

CellAge

This gene is present as PTPN1