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[1826] Eller et al. (2006), A role for WRN in telomere-based DNA damage responses, PubMed
[1794] Agrelo et al. (2006), Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer, PubMed
[1825] Cheng et al. (2006), Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links, PubMed
[1588] Harrigan et al. (2006), The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta, PubMed
[1585] Kuningas et al. (2006), Impact of genetic variations in the WRN gene on age related pathologies and mortality, PubMed
[1580] Davis et al. (2005), Prevention of accelerated cell aging in Werner syndrome using a p38 mitogen-activated protein kinase inhibitor, PubMed
[1572] Szekely et al. (2005), Werner protein protects nonproliferating cells from oxidative DNA damage, PubMed
[1519] Lan et al. (2005), Accumulation of Werner protein at DNA double-strand breaks in human cells, PubMed
[1511] Hirai et al. (2005), WRN gene 1367 Arg allele protects against development of type 2 diabetes mellitus, PubMed
[1510] Karmakar and Bohr (2005), Cellular dynamics and modulation of WRN protein is DNA damage specific, PubMed
[1509] Friedemann et al. (2005), Nuclear DNA helicase II (RNA helicase A) interacts with Werner syndrome helicase and stimulates its exonuclease activity, PubMed
[1332] Ozgenc and Loeb (2005), Current advances in unraveling the function of the Werner syndrome protein, PubMed
[1329] Bohr (2005), Deficient DNA repair in the human progeroid disorder, Werner syndrome, PubMed
[1330] Kyng et al. (2005), Gene expression responses to DNA damage are altered in human aging and in Werner Syndrome, PubMed
[1526] Cheng et al. (2005), Werner syndrome protein associates with gamma H2AX in a manner that depends upon Nbs1, PubMed
[1265] Lee et al. (2005), Pathways and functions of the Werner syndrome protein, PubMed
[1241] de Magalhaes et al. (2005), The influence of genes on the aging process of mice: a statistical assessment of the genetics of aging, PubMed
[1242] Shimamoto et al. (2004), Molecular biology of Werner syndrome, PubMed
[1149] Du et al. (2004), Telomere shortening exposes functions for the mouse werner and bloom syndrome genes, PubMed
[1139] Kipling et al. (2004), What can progeroid syndromes tell us about human aging?, PubMed
[1136] Comai and Li (2004), The Werner syndrome protein at the crossroads of DNA repair and apoptosis, PubMed
[1137] Dahl et al. (2004), The nuclear envelope lamina network has elasticity and a compressibility limit suggestive of a molecular shock absorber, PubMed
[1114] von Kobbe et al. (2004), Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein, PubMed
[1103] Bohr et al. (2004), Werner syndrome protein 1367 variants and disposition towards coronary artery disease in Caucasian patients, PubMed
[1104] Bendixen et al. (2004), A polymorphic marker in the first intron of the Werner gene associates with cognitive function in aged Danish twins, PubMed
[1069] Chang et al. (2004), Essential role of limiting telomeres in the pathogenesis of Werner syndrome, PubMed
[1150] Opresko et al. (2004), The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2, PubMed
[1076] Choudhary et al. (2004), Biochemical and kinetic characterization of the DNA helicase and exonuclease activities of werner syndrome protein, PubMed
[1048] Lee et al. (2004), A Werner syndrome protein homolog affects C. elegans development, growth rate, life span and sensitivity to DNA damage by acting at a DNA damage checkpoint, PubMed
[1011] Cheng et al. (2004), Linkage between werner syndrome protein and the Mre11 complex via Nbs1, PubMed
[0983] Li et al. (2004), Identification and biochemical characterization of a Werner syndrome protein complex with Ku70/80 and PARP-1, PubMed
[0592] Machwe et al. (2004), TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA, PubMed
[1003] Grandori et al. (2004), Functional link between Myc and the Werner gene in tumorigenesis, PubMed
[1053] Laursen et al. (2003), RecQ helicases and topoisomerase III in cancer and aging, PubMed
[0487] Laine et al. (2003), Werner protein stimulates topoisomerase I DNA relaxation activity, PubMed
[0406] von Kobbe et al. (2003), Central role for the Werner syndrome protein/poly(ADP-ribose) polymerase 1 complex in the poly(ADP-ribosyl)ation pathway after DNA damage, PubMed
[0149] Kyng et al. (2003), Gene expression profiling in Werner syndrome closely resembles that of normal aging, PubMed
[0454] Partridge et al. (2003), DNA damage modulates nucleolar interaction of the Werner protein with the AAA ATPase p97/VCP, PubMed
[0147] Chen et al. (2003), WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair, PubMed
[0223] Grandori et al. (2003), Werner syndrome protein limits MYC-induced cellular senescence, PubMed
[0172] Bai and Murnane (2003), Telomere instability in a human tumor cell line expressing a dominant-negative WRN protein, PubMed
[0443] Bachrati and Hickson (2003), RecQ helicases: suppressors of tumorigenesis and premature aging, PubMed
[0168] Opresko et al. (2003), Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process, PubMed
[0727] Baynton et al. (2003), WRN interacts physically and functionally with the recombination mediator protein RAD52, PubMed
[1520] Harrigan et al. (2003), The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity, PubMed
[1078] Rodriguez-Lopez et al. (2002), Asymmetry of DNA replication fork progression in Werner's syndrome, PubMed
[0170] Orren et al. (2002), The Werner syndrome helicase/exonuclease (WRN) disrupts and degrades D-loops in vitro, PubMed
[0511] Blander et al. (2002), DNA damage-induced translocation of the Werner helicase is regulated by acetylation, PubMed
[1305] Li and Comai (2002), Displacement of DNA-PKcs from DNA ends by the Werner syndrome protein, PubMed
[0444] Mohaghegh and Hickson (2002), Premature aging in RecQ helicase-deficient human syndromes, PubMed
[0167] Opresko et al. (2002), Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases, PubMed
[1425] Hoopes et al. (2002), Mutations in DNA replication genes reduce yeast life span, PubMed
[0819] Motonaga et al. (2002), Age related expression of Werner's syndrome protein in selected tissues and coexpression of transcription factors, PubMed
[0558] Karmakar et al. (2002), Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation, PubMed
[1304] Oshima et al. (2002), Lack of WRN results in extensive deletion at nonhomologous joining ends, PubMed
[0584] Brosh et al. (2001), Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity, PubMed
[0440] Shen and Loeb (2001), Unwinding the molecular basis of the Werner syndrome, PubMed
[1779] Lebel et al. (2001), Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase, PubMed
[0922] Kamath-Loeb et al. (2001), Interactions between the Werner syndrome helicase and DNA polymerase delta specifically facilitate copying of tetraplex and hairpin structures of the d(CGG)n trinucleotide repeat sequence, PubMed
[0652] Mohaghegh and Hickson (2001), DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders, PubMed
[0594] Li and Comai (2001), Requirements for the nucleolytic processing of DNA ends by the Werner syndrome protein-Ku70/80 complex, PubMed
[0055] Martin and Oshima (2000), Lessons from human progeroid syndromes, PubMed
[0062] Pichierri et al. (2000), Werner's syndrome cell lines are hypersensitive to camptothecin-induced chromosomal damage, PubMed
[0923] Szekely et al. (2000), Werner protein recruits DNA polymerase delta to the nucleolus, PubMed
[0148] Blander et al. (2000), The Werner syndrome protein contributes to induction of p53 by DNA damage, PubMed
[0171] Li and Comai (2000), Functional interaction between Ku and the werner syndrome protein in DNA end processing, PubMed
[0903] Kawabe et al. (2000), Covalent modification of the Werner's syndrome gene product with the ubiquitin-related protein, SUMO-1, PubMed
[0919] Kamath-Loeb et al. (2000), Functional interaction between the Werner syndrome protein and DNA polymerase delta, PubMed
[1704] Lombard et al. (2000), Mutations in the WRN gene in mice accelerate mortality in a p53-null background, PubMed
[0061] Pichierri et al. (2000), Werner's syndrome lymphoblastoid cells are hypersensitive to topoisomerase II inhibitors in the G2 phase of the cell cycle, PubMed
[0650] Lindor et al. (2000), Rothmund-Thomson syndrome due to RECQ4 helicase mutations: report and clinical and molecular comparisons with Bloom syndrome and Werner syndrome, PubMed
[0441] Brosh et al. (1999), Functional and physical interaction between WRN helicase and human replication protein A, PubMed
[0169] Spillare et al. (1999), p53-mediated apoptosis is attenuated in Werner syndrome cells, PubMed
[0730] Lebel and Leder (1998), A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity, PubMed
[0058] Huang et al. (1998), The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease, PubMed
[0940] Wu et al. (1998), Effect of age and apoptosis on the mouse homologue of the huWRN gene, PubMed
[0442] Shen et al. (1998), Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A, PubMed
[0056] Goto (1997), Hierarchical deterioration of body systems in Werner's syndrome: implications for normal ageing, PubMed
[0057] Gray et al. (1997), The Werner syndrome protein is a DNA helicase, PubMed
[0238] Pesce and Rothe (1996), The premature aging syndromes, PubMed
[0016] Yu et al. (1996), Positional cloning of the Werner's syndrome gene, PubMed
[0151] Martin (1978), Genetic syndromes in man with potential relevance to the pathobiology of aging, PubMed
[1012] Werner Syndrome Mutational Database
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