GenAge entry for WRN (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in humans

Gene name (HAGRID: 13)

HGNC symbol
WRN 
Aliases
RECQ3; RECQL2; RECQL3 
Common name
Werner syndrome, RecQ helicase-like 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in humans
Description

Werner syndrome (WS), caused by mutations in WRN, is probably the most dramatic segmental progeroid syndrome. Although there are differences between the pathobiology of normal ageing and the phenotype of WS, the age-related changes of WS patients are remarkably similar to normal ageing, only they occur at earlier ages [56].

WRN-deficient mice display reduced embryonic survival, increased tumour formation, and their fibroblasts show features similar to those found in fibroblasts derived from WS patients such as a premature loss of proliferative capacity, but their ageing process appears unaltered [730]. Combining late-generation mice without TERC, and hence with short telomeres, with WRN mutations results in a phenotype resembling accelerated ageing somewhat reminiscent from WS [1069].

WRN is a helicase and exonuclease involved in many DNA repair and processing pathways [1265]. Its exact functions remain unknown, but it is one of the strongest candidates for genes influencing human ageing.

Cytogenetic information

Cytogenetic band
8p12-p11.2
Location
31,010,319 bp to 31,150,818 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser

Protein information

Gene Ontology
Process: GO:0000723; telomere maintenance
GO:0000731; DNA synthesis involved in DNA repair
GO:0001302; replicative cell aging
GO:0006200; ATP catabolic process
GO:0006259; DNA metabolic process
GO:0006260; DNA replication
GO:0006284; base-excision repair
GO:0006302; double-strand break repair
GO:0006310; DNA recombination
GO:0006974; cellular response to DNA damage stimulus
GO:0006979; response to oxidative stress
And 13 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005813; centrosome
GO:0032389; MutLalpha complex
Function: GO:0000287; magnesium ion binding
GO:0000403; Y-form DNA binding
GO:0000405; bubble DNA binding
GO:0003677; DNA binding
GO:0003678; DNA helicase activity
GO:0004003; ATP-dependent DNA helicase activity
GO:0004386; helicase activity
GO:0004527; exonuclease activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008408; 3'-5' exonuclease activity
And 9 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, NBN, PARP1, BRCA1, BLM, VCP, TOP1, UBE2I, PRKDC, XRCC5, PCNA, FEN1, TERF2, XRCC6, POLD1, RAD52, SP1, SUMO1, H2AFX, POLB
STRING interaction network
Protein-Protein network diagram for WRN

Retrieve sequences for WRN

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
wrn-1
Danio rerio
wrn
Mus musculus
Wrn
Rattus norvegicus
Wrn
Saccharomyces cerevisiae
SGS1

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as SGS1
LongevityMap
  • This gene is present as WRN

Selected references

External links

EPD
NM_000553
ORF Accession
NM_000553
CDS Accession
NP_000544
OMIM
604611
HPRD
05212
Ensembl
WRN
UniProt/Swiss-Prot
WRN_HUMAN
GeneCards
WRN
Entrez Gene
7486
UniGene
632050
GenAtlas
WRN
Internet
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