GenAge entry for RAE1 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 241)

HGNC symbol
RAE1 
Aliases
Mnrp41 
Common name
ribonucleic acid export 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

In yeast, RAE1 is involved in RNA export. Probably, RAE1 is involved in nucleocytoplasmic transport. The RAE1 gene encodes different isoforms. Haploinsufficiency of both RAE1 and BUB3 in mice, but not haploinsufficiency of either gene by itself, reduces lifespan and appears to accelerate ageing [1594]. RAE1-null mice are embryonic lethal [1597].

Cytogenetic information

Cytogenetic band
20q13.31
Location
57,351,089 bp to 57,378,463 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000972; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
GO:0006406; mRNA export from nucleus
GO:0006409; tRNA export from nucleus
GO:0006606; protein import into nucleus
GO:0007077; mitotic nuclear envelope disassembly
GO:0010827; regulation of glucose transport
GO:0016032; viral process
GO:0016925; protein sumoylation
GO:0019083; viral transcription
GO:0031047; gene silencing by RNA
GO:0071407; cellular response to organic cyclic compound
And 3 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005635; nuclear envelope
GO:0005643; nuclear pore
GO:0005730; nucleolus
GO:0005737; cytoplasm
Function: GO:0003723; RNA binding
GO:0008017; microtubule binding
GO:0043130; ubiquitin binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, TXN, SOD1, BUB1B, POLA1, GSK3A
STRING interaction network
Protein-Protein network diagram for RAE1

Retrieve sequences for RAE1

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
rae-1
Danio rerio
rae1
Drosophila melanogaster
Rae1
Mus musculus
Rae1
Rattus norvegicus
Rae1
Saccharomyces cerevisiae
GLE2
Schizosaccharomyces pombe
rae1

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Rae1

Selected references

External links

EPD
HS_RAE1
ORF Accession
NM_003610
CDS Accession
NP_003601
OMIM
603343
HPRD
11939
Ensembl
RAE1
UniProt/Swiss-Prot
RAE1L_HUMAN
GeneCards
RAE1
Entrez Gene
8480
GenAtlas
RAE1
Internet
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