Cell Senescence Entries for PDPK1

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90, MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Induces
Observations
A library of 200 constitutively activated kinases was screened in order to identify kinases whose constitutive expression decreased cell proliferation and induced expression of senescence markers; p16 and SASP components. A total of 33 kinases showed pro-senescence effects (particularly MAP3K7, PRKCD, and MATK); kinases with strong pro-senescence effects, induced expression of SASP-component genes (e.g. IL1A, IL1B, IL6 and IL8) through activation of an NF-kappaB-dependent transcriptional program. Inhibition of the NF-kappaB, p53, or Rb pathway proved insufficient to prevent kinase-triggered cell cycle arrest.
Primary Reference

    PDPK1 Gene Information

    HGNC symbol
    PDPK1 
    Aliases
    PDK1; PDPK2; PDPK2P; PRO0461 
    Common name
    3-phosphoinositide dependent protein kinase 1 
    Entrez Id
    5170
    Description

    PDPK1 Ontologies

    Gene Ontology
    Process: GO:38095; Fc-epsilon receptor signaling pathway
    GO:31295; T cell costimulation
    GO:50852; T cell receptor signaling pathway
    GO:30036; actin cytoskeleton organization
    GO:32148; activation of protein kinase B activity
    GO:19722; calcium-mediated signaling
    GO:16477; cell migration
    GO:1990416; cellular response to brain-derived neurotrophic factor stimulus
    GO:71364; cellular response to epidermal growth factor stimulus
    GO:32869; cellular response to insulin stimulus
    GO:7173; epidermal growth factor receptor signaling pathway
    And 26 more GO terms
    Cellular component: GO:42995; cell projection
    GO:5737; cytoplasm
    GO:31410; cytoplasmic vesicle
    GO:5829; cytosol
    GO:5925; focal adhesion
    GO:5622; intracellular
    GO:16020; membrane
    GO:5654; nucleoplasm
    GO:43204; perikaryon
    GO:5886; plasma membrane
    GO:14069; postsynaptic density
    And 1 more GO terms
    Function: GO:4676; 3-phosphoinositide-dependent protein kinase activity
    GO:5524; ATP binding
    GO:5158; insulin receptor binding
    GO:16301; kinase activity
    GO:16004; phospholipase activator activity
    GO:43274; phospholipase binding
    GO:5515; protein binding
    GO:19901; protein kinase binding
    GO:4674; protein serine/threonine kinase activity
    Show all GO terms

    Homologs of PDPK1 in Model Organisms

    Caenorhabditis elegans
    pdk-1
    Danio rerio
    pdpk1a
    Danio rerio
    pdpk1b
    Drosophila melanogaster
    Pdk1
    Mus musculus
    Pdpk1
    Rattus norvegicus
    Pdpk1
    Saccharomyces cerevisiae
    PKH2
    Saccharomyces cerevisiae
    PKH3
    Saccharomyces cerevisiae
    PKH1

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as pdk-1
    • A homolog of this gene for Saccharomyces cerevisiae is present as PKH1
    • A homolog of this gene for Saccharomyces cerevisiae is present as PKH3
    • A homolog of this gene for Saccharomyces cerevisiae is present as PKH2
    GenAge human genes
    • This gene is present as PDPK1
    GenDR gene manipulations
    • A homolog of this gene for Saccharomyces cerevisiae is present as PKH2
    LongevityMap
    • This gene is present as PDPK1

    External links

    OMIM
    605213
    Ensembl
    ENSG00000140992
    Entrez Gene
    5170
    UniGene
    459691
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    PDPK1
    GeneCards
    PDPK1