GenAge entry for PRKCA (Homo sapiens)

Gene name (HAGRID: 99)

HGNC symbol: PRKCA
Aliases: PKCA
Common name: protein kinase C, alpha

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description: PRKCA is a phorbol ester receptor involved in signal transduction. It appears to interact with many proteins, including some that have been related to ageing, such as LMNA and INSR. In the medfly, PRKCA levels are age-dependent [535]. PRKCA has not been directly related to human ageing.

Cytogenetic information

Cytogenetic band: 17q22-q23.
Location: 66,302,808 bp to 66,810,744 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0001525; angiogenesis
GO:0001938; positive regulation of endothelial cell proliferation
GO:0002159; desmosome assembly
GO:0006468; protein phosphorylation
GO:0007077; mitotic nuclear envelope disassembly
GO:0007155; cell adhesion
GO:0007190; activation of adenylate cyclase activity
GO:0007194; negative regulation of adenylate cyclase activity
GO:0010595; positive regulation of endothelial cell migration
GO:0010613; positive regulation of cardiac muscle hypertrophy
GO:0018105; peptidyl-serine phosphorylation
GO:0030168; platelet activation
GO:0030335; positive regulation of cell migration
GO:0031666; positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0034351; negative regulation of glial cell apoptotic process
GO:0035408; histone H3-T6 phosphorylation
GO:0035556; intracellular signal transduction
GO:0043488; regulation of mRNA stability
GO:0043536; positive regulation of blood vessel endothelial cell migration
GO:0045651; positive regulation of macrophage differentiation
GO:0045766; positive regulation of angiogenesis
GO:0045785; positive regulation of cell adhesion
GO:0045931; positive regulation of mitotic cell cycle
GO:0050796; regulation of insulin secretion
GO:0070374; positive regulation of ERK1 and ERK2 cascade
GO:0070555; response to interleukin-1
GO:0090330; regulation of platelet aggregation
GO:0097190; apoptotic signaling pathway
GO:2000707; positive regulation of dense core granule biogenesis

Cellular component:

GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005783; endoplasmic reticulum
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0031966; mitochondrial membrane
GO:0048471; perinuclear region of cytoplasm
GO:0070062; extracellular exosome

Function:

GO:0004672; protein kinase activity
GO:0004674; protein serine/threonine kinase activity
GO:0004697; protein kinase C activity
GO:0004698; calcium-dependent protein kinase C activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008270; zinc ion binding
GO:0019899; enzyme binding
GO:0035403; histone kinase activity (H3-T6 specific)

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: LMNA, EGFR, PLCG2, HSP90AA1, TOP2A, EP300, GSK3B, PRKCA, FAS, YWHAZ, LMNB1, NFKBIA, MTOR, CTNNB1, CDKN2A, PPARG, NFE2L2, GSK3A, IKBKB, RICTOR
STRING interaction network

Retrieve sequences for PRKCA

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: pkc-2
Danio rerio: prkca
Danio rerio: PRKCA (1 of many)
Drosophila melanogaster: Pkc53E
Drosophila melanogaster: inaC
Mus musculus: Prkca
Rattus norvegicus: Prkca
Saccharomyces cerevisiae: PKC1

In other databases

LongevityMap

This gene is present as PRKCA