GenAge entry for GSK3A (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 295)

HGNC symbol: GSK3A
Aliases
Common name: glycogen synthase kinase 3 alpha

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description: GSK3A is involved in the control of several other proteins, including JUN, and signaling pathways like WNT and PI3K. It has been associated with Alzheimer disease [3426]. In mice, knockout of GSK3A results in a phenotype resembling accelerated ageing, including premature death, cardiac abnormalities and sarcopenia [3256].

Cytogenetic information

Cytogenetic band: 19q13.2
Location: 42,230,186 bp to 42,242,584 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0003073; regulation of systemic arterial blood pressure
GO:0003214; cardiac left ventricle morphogenesis
GO:0005977; glycogen metabolic process
GO:0006468; protein phosphorylation
GO:0007212; dopamine receptor signaling pathway
GO:0007399; nervous system development
GO:0008286; insulin receptor signaling pathway
GO:0010905; negative regulation of UDP-glucose catabolic process
GO:0016055; Wnt signaling pathway
GO:0030819; positive regulation of cAMP biosynthetic process
GO:0032007; negative regulation of TOR signaling
GO:0032869; cellular response to insulin stimulus
GO:0036016; cellular response to interleukin-3
GO:0036498; IRE1-mediated unfolded protein response
GO:0043161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045719; negative regulation of glycogen biosynthetic process
GO:0045732; positive regulation of protein catabolic process
GO:0045823; positive regulation of heart contraction
GO:0046325; negative regulation of glucose import
GO:0046627; negative regulation of insulin receptor signaling pathway
GO:0061052; negative regulation of cell growth involved in cardiac muscle cell development
GO:0071879; positive regulation of adrenergic receptor signaling pathway
GO:0090090; negative regulation of canonical Wnt signaling pathway
GO:0097192; extrinsic apoptotic signaling pathway in absence of ligand
GO:0099565; chemical synaptic transmission, postsynaptic
GO:1901030; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1903146; regulation of mitophagy
GO:1903955; positive regulation of protein targeting to mitochondrion
GO:1904227; negative regulation of glycogen synthase activity, transferring glucose-1-phosphate
GO:2000077; negative regulation of type B pancreatic cell development
GO:2000466; negative regulation of glycogen (starch) synthase activity
GO:2000467; positive regulation of glycogen (starch) synthase activity

Cellular component:

GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0030877; beta-catenin destruction complex
GO:0098794; postsynapse

Function:

GO:0004674; protein serine/threonine kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0034236; protein kinase A catalytic subunit binding
GO:0050321; tau-protein kinase activity

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: AKT1, MYC, PRKCD, HSP90AA1, PRKCA, PRKDC, AR, FOXM1, CREB1, MAPT, CTNNB1, RAE1, RICTOR
STRING interaction network

Retrieve sequences for GSK3A

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: gsk-3
Danio rerio: gsk3aa
Danio rerio: gsk3ab
Drosophila melanogaster: sgg
Saccharomyces cerevisiae: MRK1
Saccharomyces cerevisiae: RIM11
Schizosaccharomyces pombe: gsk3

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as RIM11
A homolog of this gene for Schizosaccharomyces pombe is present as gsk3

CellAge

This gene is present as GSK3A