Saccharomyces cerevisiae GenDR Dietary Restriction Gene Manipulation: SCH9

Gene Information (Entrez Gene ID: 856612)

Symbol
SCH9
Aliases
HRM2 KOM1
Name
serine/threonine protein kinase SCH9
Organism
Saccharomyces cerevisiae (AnAge)
Entrez Gene ID
856612

Potential relevance to dietary restriction and ageing

Observations

Transposon-mediated mutagenesis of SCH9 increases resistance to oxidants and thermal stress as well as extends chronological lifespan by 30%. SCH9 deletion increases chronological lifespan by up to threefold. [2346]. Deletion of SCH9 also increases replicative lifespan by 18% (in DBY746) [2271]. SCH9 deletion increases the replicative lifespan by 40% in the alpha strain [2504]. The extended lifespan of SCH9 deletion mutants is not further extended by low glucose DR and is independent of Sir2 [1570]. Water restriction further increases chronological lifespan of sch9Delta [2556].

References

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as akt-1
    • This gene is present as SCH9
    • A homolog of this gene for Caenorhabditis elegans is present as sgk-1
    • A homolog of this gene for Drosophila melanogaster is present as Akt1
    • A homolog of this gene for Mus musculus is present as Akt1
    • A homolog of this gene for Mus musculus is present as Akt2
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as AKT1
    GenAge microarray genes
    • A homolog of this gene for Homo sapiens is present as SGK1
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as AKT1
    • A homolog of this gene for Homo sapiens is present as SGK1
    • A homolog of this gene for Homo sapiens is present as AKT3
    • A homolog of this gene for Homo sapiens is present as SGK3
    CellAge
    • A homolog of this gene for Homo sapiens is present as AKT1
    • A homolog of this gene for Homo sapiens is present as SGK1
    • A homolog of this gene for Homo sapiens is present as STK32C

    Homologs

    Caenorhabditis elegans
    akt-2
    Caenorhabditis elegans
    sgk-1
    Caenorhabditis elegans
    C56G2.5
    Caenorhabditis elegans
    akt-1
    Caenorhabditis elegans
    M03C11.1
    Danio rerio
    sgk2b
    Danio rerio
    akt3a
    Danio rerio
    sgk1
    Danio rerio
    akt2l
    Danio rerio
    AKT1
    Danio rerio
    sgk3
    Danio rerio
    akt2
    Danio rerio
    stk32a
    Danio rerio
    sgk2a
    Danio rerio
    akt3b
    Danio rerio
    si:ch211-195b13.1
    Drosophila melanogaster
    Akt1
    Drosophila melanogaster
    CG32944
    Homo sapiens
    AKT2
    Homo sapiens
    SGK1
    Homo sapiens
    STK32A
    Homo sapiens
    C8orf44-SGK3
    Homo sapiens
    SGK2
    Homo sapiens
    STK32C
    Homo sapiens
    AKT3
    Homo sapiens
    STK32B
    Homo sapiens
    SGK3
    Homo sapiens
    AKT1
    Mus musculus
    Stk32c
    Mus musculus
    Sgk2
    Mus musculus
    Akt3
    Mus musculus
    Sgk1
    Mus musculus
    Akt1
    Mus musculus
    Akt2
    Mus musculus
    Stk32b
    Mus musculus
    Stk32a
    Mus musculus
    Sgk3
    Rattus norvegicus
    Akt1
    Rattus norvegicus
    Sgk2
    Rattus norvegicus
    Sgk3
    Rattus norvegicus
    Akt2
    Rattus norvegicus
    Stk32b
    Rattus norvegicus
    Stk32c
    Rattus norvegicus
    Stk32a
    Rattus norvegicus
    Sgk1
    Rattus norvegicus
    Akt3
    Schizosaccharomyces pombe
    sck1

    External links

    Saccharomyces Genome Database
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    Ensembl
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    Entrez Gene
    ID 856612
    Homologues
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    UniProt
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    Internet
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