LongevityMap Gene
Gene details
- HGNC symbol
- SGK3
- Aliases
- CISK; SGK2; SGKL
- Common name
- serum/glucocorticoid regulated kinase family member 3
- Description
- This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 8q13.1
- UCSC Genome Browser
- View 8q13.1 on the UCSC genome browser
- OMIM
- 607591
- Ensembl
- ENSG00000104205
- UniProt/Swiss-Prot
- A0A024R807_HUMAN
- Entrez Gene
- 23678
- UniGene
- 613417
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- sgk-1
- Danio rerio
- sgk3
- Mus musculus
- Sgk3
- Rattus norvegicus
- Sgk3
- Saccharomyces cerevisiae
- SCH9
- Saccharomyces cerevisiae
- YPK1
- Saccharomyces cerevisiae
- YPK2
In other databases
- GenAge model organism genes
- GenDR gene manipulations
- A homolog of this gene for Saccharomyces cerevisiae is present as SCH9
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- Dutch
- Study Design
- Studied genetic variation in the insulin/insulin-like growth factor signaling (IIS) pathway and in the telomere maintenance pathway for associations with longevity in 403 unrelated nonagenarians and 1,670 younger controls
- Conclusions
- SNP sets in both pathways were associated with longevity with the association of the IIS pathway defined by several genes (AKT1, AKT3, FOXO4, IGF2, INS, PIK3CA, SGK, SGK2, and YWHAG), while the telomere maintenance pathway seemed to be mainly determined by POT1 since only these genes showed an association with longevity
- Indentifier
- SGK3
- Reference