LongevityMap Gene
Gene details
- HGNC symbol
- AKT3
- Aliases
- MPPH; PKBG; MPPH2; PRKBG; STK-2; PKB-GAMMA; RAC-gamma; RAC-PK-gamma
- Common name
- AKT serine/threonine kinase 3
- Description
- The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 1q43-q44
- UCSC Genome Browser
- View 1q43-q44 on the UCSC genome browser
- OMIM
- 611223
- Ensembl
- ENSG00000117020
- UniProt/Swiss-Prot
- AKT3_HUMAN
- Entrez Gene
- 10000
- UniGene
- 498292
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- akt-1
- Caenorhabditis elegans
- akt-2
- Danio rerio
- akt3b
- Danio rerio
- akt3a
- Drosophila melanogaster
- Akt1
- Mus musculus
- Akt3
- Rattus norvegicus
- Akt3
- Saccharomyces cerevisiae
- SCH9
- Saccharomyces cerevisiae
- YPK1
- Saccharomyces cerevisiae
- YPK2
In other databases
- GenAge model organism genes
- GenDR gene manipulations
- A homolog of this gene for Saccharomyces cerevisiae is present as SCH9
- CellAge
- This gene is present as AKT3
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- Dutch
- Study Design
- Studied genetic variation in the insulin/insulin-like growth factor signaling (IIS) pathway and in the telomere maintenance pathway for associations with longevity in 403 unrelated nonagenarians and 1,670 younger controls
- Conclusions
- SNP sets in both pathways were associated with longevity with the association of the IIS pathway defined by several genes (AKT1, AKT3, FOXO4, IGF2, INS, PIK3CA, SGK, SGK2, and YWHAG), while the telomere maintenance pathway seemed to be mainly determined by POT1 since only these genes showed an association with longevity
- Indentifier
- AKT3
- Reference