Cell Senescence Entries for STK32C

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90, MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Induces
Observations
A library of 200 constitutively activated kinases was screened in order to identify kinases whose constitutive expression decreased cell proliferation and induced expression of senescence markers; p16 and SASP components. A total of 33 kinases showed pro-senescence effects (particularly MAP3K7, PRKCD, and MATK); kinases with strong pro-senescence effects, induced expression of SASP-component genes (e.g. IL1A, IL1B, IL6 and IL8) through activation of an NF-kappaB-dependent transcriptional program. Inhibition of the NF-kappaB, p53, or Rb pathway proved insufficient to prevent kinase-triggered cell cycle arrest.
Primary Reference

    STK32C Gene Information

    HGNC symbol
    STK32C 
    Aliases
    PKE; YANK3 
    Common name
    serine/threonine kinase 32C 
    Entrez Id
    282974
    Description
    The protein encoded by this gene is a member of the serine/threonine protein kinase family. It is thought that this family member is functional in brain due to its high expression levels there. DNA methylation differences have been found in this gene in monozygotic twins that are discordant for adolescent depression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

    STK32C Ontologies

    Gene Ontology
    Process: GO:35556; intracellular signal transduction
    GO:18105; peptidyl-serine phosphorylation
    Cellular component: GO:5622; intracellular
    Function: GO:5524; ATP binding
    GO:46872; metal ion binding
    GO:4674; protein serine/threonine kinase activity
    Show all GO terms

    Homologs of STK32C in Model Organisms

    Caenorhabditis elegans
    M03C11.1
    Drosophila melanogaster
    CG32944
    Mus musculus
    Stk32c
    Rattus norvegicus
    Stk32c
    Saccharomyces cerevisiae
    SCH9
    Saccharomyces cerevisiae
    YPK2
    Saccharomyces cerevisiae
    YPK1

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as SCH9
    • A homolog of this gene for Saccharomyces cerevisiae is present as YPK1
    GenDR gene manipulations
    • A homolog of this gene for Saccharomyces cerevisiae is present as SCH9

    External links

    OMIM
    Ensembl
    ENSG00000165752
    Entrez Gene
    282974
    UniGene
    469002
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    STK32C
    GeneCards
    STK32C