LongevityMap Gene
Gene details
- HGNC symbol
- SGK1
- Aliases
- SGK
- Common name
- serum/glucocorticoid regulated kinase 1
- Description
- This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
- Cytogenetic Location
- 6q23.2
- UCSC Genome Browser
- View 6q23.2 on the UCSC genome browser
- OMIM
- 602958
- Ensembl
- ENSG00000118515
- UniProt/Swiss-Prot
- B7Z325_HUMAN
- Entrez Gene
- 6446
- UniGene
- 510078
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- sgk-1
- Danio rerio
- sgk1
- Mus musculus
- Sgk1
- Rattus norvegicus
- Sgk1
- Saccharomyces cerevisiae
- SCH9
- Saccharomyces cerevisiae
- YPK1
- Saccharomyces cerevisiae
- YPK2
In other databases
- GenAge model organism genes
- GenAge microarray genes
- This gene is present as SGK1
- GenDR gene manipulations
- A homolog of this gene for Saccharomyces cerevisiae is present as SCH9
- CellAge
- This gene is present as SGK1
Studies (2)
Significant/Non-significant: 2/0
Study 1
- Longevity Association
- Significant
- Population
- Dutch
- Study Design
- Studied genetic variation in the insulin/insulin-like growth factor signaling (IIS) pathway and in the telomere maintenance pathway for associations with longevity in 403 unrelated nonagenarians and 1,670 younger controls
- Conclusions
- SNP sets in both pathways were associated with longevity with the association of the IIS pathway defined by several genes (AKT1, AKT3, FOXO4, IGF2, INS, PIK3CA, SGK, SGK2, and YWHAG), while the telomere maintenance pathway seemed to be mainly determined by POT1 since only these genes showed an association with longevity
- Indentifier
- SGK1
- Reference
Study 2
- Longevity Association
- Significant
- Population
- Dutch
- Study Design
- 1,018 SNPs within a 10-kb window around 40 mTOR signalling genes were studied for differences in variation between 417 unrelated nonagenarian participants and 476 younger controls
- Conclusions
- As a whole, there was a significant association of genetic variation in the mTOR pathway and familial longevity, though no individual gene was significant after correcting for multiple hypothesis testing
- Indentifier
- SGK1
- Reference