GenAge entry for IGFBP2 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 279)

HGNC symbol: IGFBP2
Aliases: IBP2
Common name: insulin-like growth factor binding protein 2, 36kDa

Potential relevance to the human ageing process

Main reason for selection

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Description

IGF Binding Protein 2 is encoded by the leptin(LEP)-regulated IGFBP2 gene and binds IGF proteins, especially IGF2. IGFBP2 inhibits IGF-mediated growth and developmental rates. IGFBP2 has oncogenic potential and is involved in breast cancer and glioma progression, a process which is mediated through its RGD-motif [4343].

In mice, overexpression of IGFBP2 reverses diabetes in insulin-resistant and diet-induced obese mice, as well as insulin-deficient streptozotocin-treated mice [2201]. Mice overexpressing normal IGFBP2 and IGFBP2 lacking the RGD-motif both exhibit growth impairment. However, whilst mice overexpressing IGFBP2 were shown to have delayed sexual maturation and increased life expectancy when compared to controls, mice overexpressing the mutant variant showed no changes in these parameters. These results suggest that the RGD-motif has a major influence on IGFBP2’s pleiotropic effect and that somatic growth/time of sexual maturity may be less closely related to life expectancy than previously thought [4343].

Although it is tempting to suggest a role for IGFBP2 in age-related diseases and perhaps in ageing, due to its links to IGFs and LEP, so far, no direct evidence linking IGFBP2 to human ageing is available.

Cytogenetic information

Cytogenetic band: 2q33-q34
Location: 216,633,404 bp to 216,664,435 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0001558; regulation of cell growth
GO:0007165; signal transduction
GO:0007565; female pregnancy
GO:0007568; aging
GO:0007584; response to nutrient
GO:0009612; response to mechanical stimulus
GO:0010226; response to lithium ion
GO:0032355; response to estradiol
GO:0032526; response to retinoic acid
GO:0032870; cellular response to hormone stimulus
GO:0042104; positive regulation of activated T cell proliferation

And 7 more GO terms

Cellular component:

GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0016324; apical plasma membrane
GO:0031410; cytoplasmic vesicle
GO:0070062; extracellular exosome

Function:

GO:0005102; receptor binding
GO:0005515; protein binding
GO:0031994; insulin-like growth factor I binding
GO:0031995; insulin-like growth factor II binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: IGF1
STRING interaction network

Retrieve sequences for IGFBP2

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: igfbp2b
Danio rerio: igfbp2a
Mus musculus: Igfbp2
Rattus norvegicus: Igfbp2

In other databases

GenDR gene expression

A homolog of this gene for Mus musculus is present as Igfbp2