GenAge entry for KL (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 17)

HGNC symbol
KL 
Aliases
 
Common name
klotho 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

The KL gene encodes two proteins: one membrane protein and one secreted transcript that acts as a circulating hormone.

Mice mutant for KL show multiple signs of accelerated ageing [20]. In contrast, overexpression of KL in mice increases lifespan by 20-30%, perhaps through a repression of intracellular INS/IGF1 signals [1485]. KL alleles have also been implicated in human longevity and age-related diseases [146]. Even though its exact functions remain a mystery, KL may be involved in calcium metabolism and in a vitamin D endocrine system. Premature ageing phenotypes in mice mutant for KL are largely rescued by keeping the animals on a vitamin-D-deficient diet [245]. KL might also exert its actions through FGF23 [1851]. It is plausible that KL plays some role in human ageing but more work is necessary to confirm this notion and elucidate the mechanisms involved.

Cytogenetic information

Cytogenetic band
13q12
Location
32,488,570 bp to 32,538,279 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser

Protein information

Gene Ontology
Process: GO:0002526; acute inflammatory response
GO:0005975; carbohydrate metabolic process
GO:0006112; energy reserve metabolic process
GO:0007173; epidermal growth factor receptor signaling pathway
GO:0007568; aging
GO:0008286; insulin receptor signaling pathway
GO:0008543; fibroblast growth factor receptor signaling pathway
GO:0030501; positive regulation of bone mineralization
GO:0038095; Fc-epsilon receptor signaling pathway
GO:0045087; innate immune response
GO:0048011; neurotrophin TRK receptor signaling pathway
And 4 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005886; plasma membrane
GO:0005887; integral to plasma membrane
GO:0016021; integral to membrane
Function: GO:0004566; beta-glucuronidase activity
GO:0004871; signal transducer activity
GO:0005104; fibroblast growth factor receptor binding
GO:0005179; hormone activity
GO:0005499; vitamin D binding
GO:0008422; beta-glucosidase activity
GO:0017134; fibroblast growth factor binding
Show all GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for KL

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
kl
Mus musculus
Kl
Rattus norvegicus
Kl

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Kl
LongevityMap
  • This gene is present as KL
  • This gene is present as KL

Selected references

External links

EPD
ORF Accession
NM_004795
CDS Accession
NP_004786
OMIM
604824
HPRD
05316
Ensembl
KL
UniProt/Swiss-Prot
KLOT_HUMAN
GeneCards
KL
Entrez Gene
9365
UniGene
524953
GenAtlas
KL
Internet
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