Cell Senescence Entries for KL

Cell Types
Lung fibroblast
Cell Lines
MRC-5, WI-38
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Downregulation of Klotho (KL) by RNA interference up-regulated p21 expression, induced a flattened and enlarged cell morphology and led to an increased SA-beta-galactosidase activity, ultimately shortening replicative lifespan and reducing the growth rate of lung fibroblasts.
Primary Reference

    KL Gene Information

    HGNC symbol
    KL 
    Aliases
     
    Common name
    klotho 
    Entrez Id
    9365
    Description
    This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. [provided by RefSeq, Jul 2008]

    KL Ontologies

    Gene Ontology
    Process: GO:165; MAPK cascade
    GO:7568; aging
    GO:55074; calcium ion homeostasis
    GO:5975; carbohydrate metabolic process
    GO:6112; energy reserve metabolic process
    GO:8543; fibroblast growth factor receptor signaling pathway
    GO:1901657; glycosyl compound metabolic process
    GO:8286; insulin receptor signaling pathway
    GO:46854; phosphatidylinositol phosphorylation
    GO:36092; phosphatidylinositol-3-phosphate biosynthetic process
    GO:48015; phosphatidylinositol-mediated signaling
    And 5 more GO terms
    Cellular component: GO:16324; apical plasma membrane
    GO:70062; extracellular exosome
    GO:5576; extracellular region
    GO:5615; extracellular space
    GO:5887; integral component of plasma membrane
    GO:5622; intracellular
    GO:5886; plasma membrane
    Function: GO:16303; 1-phosphatidylinositol-3-kinase activity
    GO:5088; Ras guanyl-nucleotide exchange factor activity
    GO:8422; beta-glucosidase activity
    GO:4566; beta-glucuronidase activity
    GO:17134; fibroblast growth factor binding
    GO:5104; fibroblast growth factor receptor binding
    GO:5179; hormone activity
    GO:46934; phosphatidylinositol-4,5-bisphosphate 3-kinase activity
    GO:4871; signal transducer activity
    GO:5499; vitamin D binding
    Show all GO terms

    Homologs of KL in Model Organisms

    Danio rerio
    kl
    Mus musculus
    Kl
    Rattus norvegicus
    Kl

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Mus musculus is present as Kl
    GenAge human genes
    • This gene is present as KL
    LongevityMap
    • This gene is present as KL

    External links

    OMIM
    604824
    Ensembl
    ENSG00000133116
    Entrez Gene
    9365
    UniGene
    524953
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    KL
    GeneCards
    KL