GenAge entry for tert (Danio rerio)
Gene information (ID: 1792)
- telomerase reverse transcriptase
- Danio rerio (AnAge)
Potential relevance to longevity and/or ageing
- First generation tert mutants, resulting from a heterozygous incross, are born healthy and develop past sexual maturity without any obvious defects. The tert mutation results in shorter telomeres and mutants die significantly earlier than their wild type siblings (average lifespan of 9 versus >22 months, p<0.005). The increase in mortality is accompanied by a consistent gradual decrease in body mass (cachexiaa), a common phenotypic alteration in aged organisms.
- % change in avg or median lifespan
- Average lifespan is more than 60% lower.
- Lifespan Effect
- Genetic Manipulation
- Longevity Category
- Primary reference
Homologs in other organisms
No homologs found