Danio rerioGenAge entry for tert (Danio rerio)

Gene information (ID: 1792)

Symbol
tert
Name
telomerase reverse transcriptase
Organism
Danio rerio (AnAge)

Potential relevance to longevity and/or ageing

Observations
First generation tert mutants, resulting from a heterozygous incross, are born healthy and develop past sexual maturity without any obvious defects. The tert mutation results in shorter telomeres and mutants die significantly earlier than their wild type siblings (average lifespan of 9 versus >22 months, p<0.005). The increase in mortality is accompanied by a consistent gradual decrease in body mass (cachexiaa), a common phenotypic alteration in aged organisms.
% change in avg or median lifespan
Average lifespan is more than 60% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Mutation
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    No homologs found

    External links

    Entrez Gene
    View on Entrez Gene database (796551)
    Homologues
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    UniProt
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    Internet
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