Cell Senescence Entries for TERT

Cell Types
Foreskin fibroblast, Retinal pigment epithelial
Cell Lines
RPE-340, BJ
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Expression of TERT (hTRT) delayed senescence in normal retinal pigment epithelial cells. RPE-340 cells were transfected with a MPSV-hTRT vector. In cells without hTRT activity (hTRT- RPE) telomere length was found to decrease. In cells that expressed telomerase activity (hTRT+ RPE) endogenous telomere length increased. hTRT+ RPE clones exceeded the mean lifepspan of hTRT- RPE by ~20 doublings, exceeding the maximal RPE life-span. hTRT- RPE clones showed high levels of SA-beta-galactosidase staining. In contrast few of the hTRT+ RPE clones showed staining.
Primary Reference

    TERT Gene Information

    HGNC symbol
    TERT 
    Aliases
    TP2; TRT; CMM9; EST2; TCS1; hTRT; DKCA2; DKCB4; hEST2; PFBMFT1 
    Common name
    telomerase reverse transcriptase 
    Entrez Id
    7015
    Description
    Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008]

    TERT Ontologies

    Gene Ontology
    Process: GO:71897; DNA biosynthetic process
    GO:22616; DNA strand elongation
    GO:32774; RNA biosynthetic process
    GO:6278; RNA-dependent DNA biosynthetic process
    GO:1904837; beta-catenin-TCF complex assembly
    GO:71456; cellular response to hypoxia
    GO:70200; establishment of protein localization to telomere
    GO:7005; mitochondrion organization
    GO:2000773; negative regulation of cellular senescence
    GO:2000352; negative regulation of endothelial cell apoptotic process
    GO:2001240; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
    And 25 more GO terms
    Cellular component: GO:16605; PML body
    GO:31379; RNA-directed RNA polymerase complex
    GO:1990572; TERT-RMRP complex
    GO:781; chromosome, telomeric region
    GO:42645; mitochondrial nucleoid
    GO:784; nuclear chromosome, telomeric region
    GO:783; nuclear telomere cap complex
    GO:5730; nucleolus
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:5886; plasma membrane
    And 3 more GO terms
    Function: GO:3677; DNA binding
    GO:3723; RNA binding
    GO:3968; RNA-directed 5'-3' RNA polymerase activity
    GO:3964; RNA-directed DNA polymerase activity
    GO:51087; chaperone binding
    GO:46872; metal ion binding
    GO:16779; nucleotidyltransferase activity
    GO:5515; protein binding
    GO:42803; protein homodimerization activity
    GO:49; tRNA binding
    GO:70034; telomerase RNA binding
    And 6 more GO terms
    Show all GO terms

    Homologs of TERT in Model Organisms

    Danio rerio
    tert
    Mus musculus
    Tert
    Rattus norvegicus
    Tert
    Saccharomyces cerevisiae
    EST2
    Schizosaccharomyces pombe
    trt1

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Mus musculus is present as Tert
    GenAge human genes
    • This gene is present as TERT
    LongevityMap
    • This gene is present as TERT

    External links

    OMIM
    187270
    Ensembl
    ENSG00000164362
    Entrez Gene
    7015
    UniGene
    492203
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    TERT
    GeneCards
    TERT