Mus musculusGenAge entry for Tert (Mus musculus)

Gene information (ID: 672)

Symbol
Tert
Aliases
TR; TP2; TRT; EST2; TCS1
Name
Telomerase reverse transcriptase
Organism
Mus musculus (AnAge)
Known functions and activities
Telomere elongation

Potential relevance to longevity and/or ageing

Observations
Overexpression of telomerase results in a high cancer incidence but also a modest lifespan extension accompanied by a lower incidence of some age-related degenerative diseases, in particular those related to kidney function and germline integrity.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    9% up to 50% extension of the median lifespan, when overexpressed in mice engineered to be cancer resistant by means of enhanced expression of the tumor suppressors p53, p16, andp19ARF.
    % change in max lifespan
    Maximum lifespan is 9-50% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Overexpression
    Longevity Category
    Pro-Longevity
    Primary reference
      Observations
      Telomerase reactivation in late generation TERT-ER mice extends telomeres, reduces DNA damage signalling and associated cellular checkpoint responses, allows resumption of proliferation in quiescent cultures, and eliminates degenerative phenotypes across multiple organs including testes, spleens and intestines.
      Lifespan Effect
      Increase
      Genetic Manipulation
      Knockin
      Longevity Category
      Pro-Longevity
      Primary reference

        In other databases

        GenAge human genes
        • A homolog of this gene for Homo sapiens is present as TERT
        LongevityMap
        • A homolog of this gene for Homo sapiens is present as TERT
        CellAge
        • A homolog of this gene for Homo sapiens is present as TERT

        Homologs in other organisms

        Danio rerio
        tert
        Homo sapiens
        TERT
        Rattus norvegicus
        Tert
        Saccharomyces cerevisiae
        EST2
        Schizosaccharomyces pombe
        trt1

        External links

        Mouse Genome Informatics
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        Ensembl
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        Entrez Gene
        View on Entrez Gene database (21752)
        Homologues
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        UniProt
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        Internet
        Search Google or Search Google Scholar