GenAge entry for SOCS2 (Homo sapiens)
Gene name (HAGRID: 271)
- HGNC symbol
- SOCS2
- Aliases
- STATI2; SSI2; SOCS-2; SSI-2; CIS2; Cish2
- Common name
- suppressor of cytokine signaling 2
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
- Description
SOCS2 is a member of the suppressor of cytokine signaling (SOCS) family and is a cytokine-inducible negative regulator of cytokine receptor signaling through the JAK/STAT pathway. The SOCS2 protein interacts with IGF1 and GH receptors IGF1R and GHR [2175] as a negative regulator of GH signaling [2177]. The lack of SOCS2 expression in the high-growth mouse increases plasma IGF1, and reduces plasma and pituitary GH1 levels. Mutant mice exhibited a reduced mean and maximal lifespan compared to wild type [2178]. SOCS2 is also involved in several types of cancer [2179].
Cytogenetic information
- Cytogenetic band
- 12q
- Location
- 93,569,822 bp to 93,576,745 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0001558; regulation of cell growth
GO:0006469; negative regulation of protein kinase activity
GO:0007259; JAK-STAT cascade
GO:0009966; regulation of signal transduction
GO:0009967; positive regulation of signal transduction
GO:0016567; protein ubiquitination
GO:0019221; cytokine-mediated signaling pathway
GO:0032355; response to estradiol
GO:0032870; cellular response to hormone stimulus
GO:0043066; negative regulation of apoptotic process
GO:0046426; negative regulation of JAK-STAT cascade
And 3 more GO terms Cellular component: GO:0005737; cytoplasm
GO:0005829; cytosol
Function: GO:0004860; protein kinase inhibitor activity
GO:0005070; SH3/SH2 adaptor activity
GO:0005131; growth hormone receptor binding
GO:0005159; insulin-like growth factor receptor binding
GO:0005515; protein binding
GO:0008269; JAK pathway signal transduction adaptor activity
Protein interactions and network
- Protein-protein interacting partners in GenAge
- GHR, IGF1R, EPOR, PTK2B, PTK2, BMI1
- STRING interaction network
Retrieve sequences for SOCS2
Homologs in model organisms
- Danio rerio
- socs2
- Drosophila melanogaster
- Socs44A
- Mus musculus
- Gm9847
- Mus musculus
- Socs2
- Rattus norvegicus
- AC124896.1
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Socs2
- LongevityMap
- This gene is present as SOCS2
- CellAge gene expression
- This gene is present as SOCS2
Selected references
External links
- EPD
- ORF Accession
- NM_003877
- CDS Accession
- NP_003868
- OMIM
- 605117
- HPRD
- 05490
- Ensembl
- SOCS2
- UniProt/Swiss-Prot
- SOCS2_HUMAN
- GeneCards
- SOCS2
- Entrez Gene
- 8835
- GenAtlas
- SOCS2
- Internet
- Search Google