Mus musculusGenAge entry for Socs2 (Mus musculus)

Gene information (ID: 826)

Symbol
Socs2
Aliases
hg; JAB; CIS2; Cish2; SSI-2; SOCS-2; AI527257; AW108012; 8
Name
Suppressor of cytokine signaling 2
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
Mutant mice exhibited a reduced mean and maximal lifespan compared to wild type. The lack of SOCS2 expression in the high-growth mouse also increases plasma IGF1, and reduces plasma and pituitary GH levels.
% change in max lifespan
Maximum lifespan is 14% lower.
% change in avg or median lifespan
Average lifespan is 35% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Mutations
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as SOCS2
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as SOCS2
    CellAge gene expression
    • A homolog of this gene for Homo sapiens is present as SOCS2

    Homologs in other organisms

    Danio rerio
    socs2
    Drosophila melanogaster
    Socs44A
    Homo sapiens
    SOCS2
    Rattus norvegicus
    AC124896.1

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (216233)
    Homologues
    Search HomoloGene
    UniProt
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    Internet
    Search Google or Search Google Scholar