LongevityMap Gene

Gene details

HGNC symbol: SOCS2
Aliases: CIS2; SSI2; Cish2; SSI-2; SOCS-2; STATI2
Common name: suppressor of cytokine signaling 2
Description: This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Cytogenetic Location: 12q22
UCSC Genome Browser: View 12q22 on the UCSC genome browser
OMIM: 605117
Ensembl: ENSG00000120833
UniProt/Swiss-Prot: A0A024RBD2_HUMAN
Entrez Gene: 8835
UniGene: 485572
1000 Genomes: 1000 Genomes

GenAge model organism genes

GenAge human genes

CellAge gene expression

Significant/Non-significant: 1/0

Longevity Association

Significant

Population

American (Caucasian)

Study Design

Genome-wide association study in 801 centenarians and 914 healthy controls

Conclusions

281 SNPs were found to discriminate between cases and controls

Indentifier

rs3782415

Reference