GenAge entry for SIRT7 (Homo sapiens)

Gene name (HAGRID: 269)

HGNC symbol: SIRT7
Aliases
Common name: sirtuin 7

Potential relevance to the human ageing process

Main reason for selection

Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing

Description

SIRT7 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. The mouse homologue, Sirt7 is involved in cell metabolism, stress resistance and proliferation [3355]. Human SIRT7 is a histone deacetylase that is recruited to target promoters by interactions with transcription factors, promoting transcriptional repression [3356]. Evidence from lower organisms and human hematopoietic stem cells (HSCs) suggest that sirtuins might be implicated in ageing.

Homozygous (but not heterozygous) Sirt7 mouse mutants showed signs of ageing-related changes and died prematurely. Mutant mice develop kyphosis and lost subcutaneous fat early in life, and showed a general decrease in stress-resistance mechanisms. They develop cardiomyopathy and are characterized by extensive fibrosis, leading to an increase in collagen III accumulation [2169], though it is not entirely clear the mice are progeroid.

In humans, levels of SIRT7 expression are significantly increased in breast cancer [2170] and in human thyroid carcinoma [2171]. Inactivation of SIRT7 in HSCs results in reduced quiescence, increased mitochondrial protein folding stress and compromises their regenerative capacity. SIRT7 expression levels are reduced in aged HSCs and SIRT7 upregulation is enough to improve their regenerative capacity [4327].

Cytogenetic information

Cytogenetic band: 17q25
Location: 81,911,939 bp to 81,918,182 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0007072; positive regulation of transcription involved in exit from mitosis
GO:0009303; rRNA transcription
GO:0070932; histone H3 deacetylation
GO:0070933; histone H4 deacetylation

Cellular component:

GO:0005730; nucleolus
GO:0005731; nucleolus organizer region
GO:0005737; cytoplasm

Function:

GO:0003682; chromatin binding
GO:0005515; protein binding
GO:0046872; metal ion binding
GO:0070403; NAD+ binding
GO:0097372; NAD-dependent histone deacetylase activity (H3-K18 specific)

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, ATM, LMNA, BLM, VCP, TOP1, PRKDC, XRCC5, XRCC6, APP, HSPA9, GSTP1, POLA1, HDAC2, H2AFX, MTOR, PPP1CA, TPP2, TP53BP1
STRING interaction network

Retrieve sequences for SIRT7

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: sirt7
Drosophila melanogaster: Sirt7
Mus musculus: Sirt7
Rattus norvegicus: Sirt7

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Sirt7

CellAge

This gene is present as SIRT7