Cell Senescence Entries for STAT5B

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Mutation
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Mallette et al. (2010) Transcriptome analysis and tumor suppressor requirements of STAT5-induced senescence. Ann N Y Acad Sci 1197(2)142-51 (PubMed)

STAT5B Gene Information

HGNC symbol
STAT5B 
Aliases
 
Common name
signal transducer and activator of transcription 5B 
Entrez Id
6777
Description
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008].

STAT5B Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:7165; signal transduction
GO:45944; positive regulation of transcription by RNA polymerase II
GO:6357; regulation of transcription by RNA polymerase II
GO:71363; cellular response to growth factor stimulus
GO:60397; growth hormone receptor signaling pathway via JAK-STAT
GO:6952; defense response
GO:19221; cytokine-mediated signaling pathway
GO:42127; regulation of cell population proliferation
GO:7259; receptor signaling pathway via JAK-STAT
GO:32355; response to estradiol
And 40 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:785; chromatin
GO:5654; nucleoplasm
GO:5829; cytosol
GO:90575; RNA polymerase II transcription regulator complex
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:46983; protein dimerization activity
GO:42802; identical protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:3682; chromatin binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:35259; glucocorticoid receptor binding
And 1 more GO terms
Show all GO terms

Homologs of STAT5B in Model Organisms

Caenorhabditis elegans
sta-1
Danio rerio
stat5a
Danio rerio
stat5b
Drosophila melanogaster
Stat92E
Mus musculus
Stat5b
Rattus norvegicus
Stat5b

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as Stat92E
GenAge human genes
  • This gene is present as STAT5B

External links

OMIM
604260
Ensembl
ENSG00000173757
Entrez Gene
6777
UniGene
595276
1000 Genomes
1000 Genomes
HPRD
GenAtlas
STAT5B
GeneCards
STAT5B