Cell Senescence Entries for STAT5B
- Cell Types
- Lung fibroblast
- Cell Lines
- IMR-90
- Cancer Cell?
- No
- Method
- Overexpression
- Type of senescence
- Replicative
- Senescence Effect
- Induces
- Observations
- STAT5B was overexpressed in normal lung fibroblasts. Constitutive activation of the JAK/STAT5 signalling pathway induced cellular senescence through the activation of the p53 and Rb tumor suppressor pathways and mitochondrial dysfunction.
- Primary Reference
STAT5B Gene Information
- HGNC symbol
- STAT5B
- Aliases
- STAT5
- Common name
- signal transducer and activator of transcription 5B
- Entrez Id
- 6777
- Description
- The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008]
STAT5B Ontologies
- Gene Ontology
-
Process: GO:6103; 2-oxoglutarate metabolic process
GO:7259; JAK-STAT cascade
GO:60397; JAK-STAT cascade involved in growth hormone signaling pathway
GO:48541; Peyer's patch development
GO:33077; T cell differentiation in thymus
GO:43029; T cell homeostasis
GO:255; allantoin metabolic process
GO:71364; cellular response to epidermal growth factor stimulus
GO:71363; cellular response to growth factor stimulus
GO:32870; cellular response to hormone stimulus
GO:6101; citrate metabolic process
And 43 more GO terms Cellular component: GO:5737; cytoplasm
GO:5829; cytosol
GO:5654; nucleoplasm
GO:5634; nucleus
Function: GO:979; RNA polymerase II core promoter sequence-specific DNA binding
GO:3682; chromatin binding
GO:35259; glucocorticoid receptor binding
GO:5515; protein binding
GO:46983; protein dimerization activity
GO:19903; protein phosphatase binding
GO:4713; protein tyrosine kinase activity
GO:4871; signal transducer activity
GO:3700; transcription factor activity, sequence-specific DNA binding
GO:1077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Homologs of STAT5B in Model Organisms
- Caenorhabditis elegans
- sta-1
- Danio rerio
- stat5a
- Danio rerio
- stat5b
- Drosophila melanogaster
- Stat92E
- Mus musculus
- Stat5b
- Rattus norvegicus
- Stat5b
In other databases
- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as Stat92E
- GenAge human genes
- This gene is present as STAT5B
External links
- OMIM
- 604260
- Ensembl
- ENSG00000173757
- Entrez Gene
- 6777
- UniGene
- 595276
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- STAT5B
- GeneCards
- STAT5B