Cell Senescence Entries for SFN
- Cell Types
- Melanoma
- Cell Lines
- SK-MEL-147, SK-MEL-19, SK-MEL-29
- Cancer Cell?
- Yes
- Method
- Overexpression
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Induces
- Primary Reference
- Schultz et al. (2009) 14-3-3sigma gene silencing during melanoma progression and its role in cell cycle control and cellular senescence. Mol Cancer 8(2)53 (PubMed)
SFN Gene Information
- HGNC symbol
- SFN
- Aliases
- YWHAS
- Common name
- stratifin
- Entrez Id
- 2810
- Description
- This gene encodes a cell cycle checkpoint protein. The encoded protein binds to translation and initiation factors and functions as a regulator of mitotic translation. In response to DNA damage this protein plays a role in preventing DNA errors during mitosis. [provided by RefSeq, Aug 2017].
SFN Ontologies
- Gene Ontology
-
Process: GO:7165; signal transduction
GO:34613; cellular protein localization
GO:45606; positive regulation of epidermal cell differentiation
GO:61436; establishment of skin barrier
GO:1836; release of cytochrome c from mitochondria
GO:43154; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:79; regulation of cyclin-dependent protein serine/threonine kinase activity
GO:3334; keratinocyte development
GO:6469; negative regulation of protein kinase activity
GO:8630; intrinsic apoptotic signaling pathway in response to DNA damage
GO:10482; regulation of epidermal cell division
And 8 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
GO:5576; extracellular region
GO:70062; extracellular exosome
GO:5615; extracellular space
Function: GO:5515; protein binding
GO:19901; protein kinase binding
GO:42802; identical protein binding
GO:45296; cadherin binding
GO:8426; protein kinase C inhibitor activity
GO:51219; phosphoprotein binding
Homologs of SFN in Model Organisms
- Caenorhabditis elegans
- M117.3
- Caenorhabditis elegans
- par-5
- Caenorhabditis elegans
- ftt-2
- Danio rerio
- ywhaqa
- Danio rerio
- ywhaqb
- Drosophila melanogaster
- 14-3-3zeta
- Mus musculus
- Sfn
- Rattus norvegicus
- LOC298795
- Rattus norvegicus
- Sfn
- Saccharomyces cerevisiae
- BMH1
- Saccharomyces cerevisiae
- BMH2
In other databases
- GenAge model organism genes
External links
- OMIM
- 601290
- Ensembl
- ENSG00000175793
- Entrez Gene
- 2810
- UniGene
- 523718
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- SFN
- GeneCards
- SFN