Cell Senescence Entries for SFN

Cell Types
Melanoma
Cell Lines
SK-MEL-147, SK-MEL-19, SK-MEL-29
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Observations
Overexpression of SFN induced cellular senescence in melanoma cells and was involved in melanoma cell senescence under genotoxic stress.
Primary Reference

    SFN Gene Information

    HGNC symbol
    SFN 
    Aliases
    YWHAS 
    Common name
    stratifin 
    Entrez Id
    2810
    Description

    SFN Ontologies

    Gene Ontology
    Process: GO:6977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
    GO:61436; establishment of skin barrier
    GO:8630; intrinsic apoptotic signaling pathway in response to DNA damage
    GO:31424; keratinization
    GO:3334; keratinocyte development
    GO:61024; membrane organization
    GO:43154; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
    GO:10839; negative regulation of keratinocyte proliferation
    GO:6469; negative regulation of protein kinase activity
    GO:71901; negative regulation of protein serine/threonine kinase activity
    GO:30307; positive regulation of cell growth
    And 8 more GO terms
    Cellular component: GO:30659; cytoplasmic vesicle membrane
    GO:5829; cytosol
    GO:70062; extracellular exosome
    GO:5615; extracellular space
    GO:5739; mitochondrion
    GO:5634; nucleus
    Function: GO:45296; cadherin binding
    GO:42802; identical protein binding
    GO:51219; phosphoprotein binding
    GO:5515; protein binding
    GO:19904; protein domain specific binding
    GO:8426; protein kinase C inhibitor activity
    GO:19901; protein kinase binding
    Show all GO terms

    Homologs of SFN in Model Organisms

    Caenorhabditis elegans
    M117.3
    Caenorhabditis elegans
    par-5
    Caenorhabditis elegans
    ftt-2
    Danio rerio
    ywhaqa
    Danio rerio
    ywhaqb
    Drosophila melanogaster
    14-3-3zeta
    Mus musculus
    Sfn
    Rattus norvegicus
    LOC298795
    Rattus norvegicus
    Sfn
    Saccharomyces cerevisiae
    BMH1
    Saccharomyces cerevisiae
    BMH2

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as ftt-2
    • A homolog of this gene for Caenorhabditis elegans is present as par-5
    • A homolog of this gene for Saccharomyces cerevisiae is present as BMH1
    • A homolog of this gene for Saccharomyces cerevisiae is present as BMH2

    External links

    OMIM
    601290
    Ensembl
    ENSG00000175793
    Entrez Gene
    2810
    UniGene
    523718
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    SFN
    GeneCards
    SFN