LongevityMap Gene
Gene details
- HGNC symbol
- YWHAG
- Aliases
- PPP1R170; 14-3-3GAMMA
- Common name
- tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
- Description
- This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 7q11.23
- UCSC Genome Browser
- View 7q11.23 on the UCSC genome browser
- OMIM
- 605356
- Ensembl
- ENSG00000170027
- UniProt/Swiss-Prot
- 1433G_HUMAN
- Entrez Gene
- 7532
- UniGene
- 744840
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- M117.3
- Caenorhabditis elegans
- ftt-2
- Caenorhabditis elegans
- par-5
- Danio rerio
- ywhag2
- Danio rerio
- ywhag1
- Drosophila melanogaster
- 14-3-3zeta
- Mus musculus
- Ywhag
- Rattus norvegicus
- Ywhag
- Saccharomyces cerevisiae
- BMH1
- Saccharomyces cerevisiae
- BMH2
In other databases
- GenAge model organism genes
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- Dutch
- Study Design
- Studied genetic variation in the insulin/insulin-like growth factor signaling (IIS) pathway and in the telomere maintenance pathway for associations with longevity in 403 unrelated nonagenarians and 1,670 younger controls
- Conclusions
- SNP sets in both pathways were associated with longevity with the association of the IIS pathway defined by several genes (AKT1, AKT3, FOXO4, IGF2, INS, PIK3CA, SGK, SGK2, and YWHAG), while the telomere maintenance pathway seemed to be mainly determined by POT1 since only these genes showed an association with longevity
- Indentifier
- YWHAG
- Reference