Cell Senescence Entries for YWHAB

Cell Types
Glioblastoma
Cell Lines
A172
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Seo et al. (2019) 14-3-3β Depletion Drives a Senescence Program in Glioblastoma Cells Through the ERK/SKP2/p27 Pathway. Mol Neurobiol 55(2)1259-1270 (PubMed)

YWHAB Gene Information

HGNC symbol
YWHAB 
Aliases
YWHAA 
Common name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta 
Entrez Id
7529
Description
This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008].

YWHAB Ontologies

Gene Ontology
Process: GO:1900740; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:43086; negative regulation of catalytic activity
GO:7165; signal transduction
GO:34613; cellular protein localization
GO:45744; negative regulation of G protein-coupled receptor signaling pathway
GO:51220; cytoplasmic sequestering of protein
GO:43085; positive regulation of catalytic activity
GO:6605; protein targeting
GO:35308; negative regulation of protein dephosphorylation
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5829; cytosol
GO:5739; mitochondrion
GO:5925; focal adhesion
GO:48471; perinuclear region of cytoplasm
GO:42470; melanosome
GO:5773; vacuole
GO:70062; extracellular exosome
GO:5774; vacuolar membrane
Function: GO:5515; protein binding
GO:42802; identical protein binding
GO:4860; protein kinase inhibitor activity
GO:19904; protein domain specific binding
GO:45296; cadherin binding
GO:19899; enzyme binding
GO:42826; histone deacetylase binding
GO:50815; phosphoserine residue binding
GO:51219; phosphoprotein binding
Show all GO terms

Homologs of YWHAB in Model Organisms

Caenorhabditis elegans
M117.3
Caenorhabditis elegans
par-5
Caenorhabditis elegans
ftt-2
Danio rerio
ywhabb
Danio rerio
ywhaba
Drosophila melanogaster
14-3-3zeta
Mus musculus
Ywhab
Rattus norvegicus
Ywhab
Saccharomyces cerevisiae
BMH1
Saccharomyces cerevisiae
BMH2

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as ftt-2
  • A homolog of this gene for Caenorhabditis elegans is present as par-5
  • A homolog of this gene for Saccharomyces cerevisiae is present as BMH1
  • A homolog of this gene for Saccharomyces cerevisiae is present as BMH2

External links

OMIM
601289
Ensembl
ENSG00000166913
Entrez Gene
7529
UniGene
643544
1000 Genomes
1000 Genomes
HPRD
GenAtlas
YWHAB
GeneCards
YWHAB