Cell Senescence Entries for YWHAB
- Cell Types
- Glioblastoma
- Cell Lines
- A172
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Seo et al. (2019) 14-3-3β Depletion Drives a Senescence Program in Glioblastoma Cells Through the ERK/SKP2/p27 Pathway. Mol Neurobiol 55(2)1259-1270 (PubMed)
YWHAB Gene Information
- HGNC symbol
- YWHAB
- Aliases
- YWHAA
- Common name
- tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
- Entrez Id
- 7529
- Description
- This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008].
YWHAB Ontologies
- Gene Ontology
-
Process: GO:1900740; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:43086; negative regulation of catalytic activity
GO:7165; signal transduction
GO:34613; cellular protein localization
GO:45744; negative regulation of G protein-coupled receptor signaling pathway
GO:51220; cytoplasmic sequestering of protein
GO:43085; positive regulation of catalytic activity
GO:6605; protein targeting
GO:35308; negative regulation of protein dephosphorylation
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5829; cytosol
GO:5739; mitochondrion
GO:5925; focal adhesion
GO:48471; perinuclear region of cytoplasm
GO:42470; melanosome
GO:5773; vacuole
GO:70062; extracellular exosome
GO:5774; vacuolar membrane
Function: GO:5515; protein binding
GO:42802; identical protein binding
GO:4860; protein kinase inhibitor activity
GO:19904; protein domain specific binding
GO:45296; cadherin binding
GO:19899; enzyme binding
GO:42826; histone deacetylase binding
GO:50815; phosphoserine residue binding
GO:51219; phosphoprotein binding
Homologs of YWHAB in Model Organisms
- Caenorhabditis elegans
- M117.3
- Caenorhabditis elegans
- par-5
- Caenorhabditis elegans
- ftt-2
- Danio rerio
- ywhabb
- Danio rerio
- ywhaba
- Drosophila melanogaster
- 14-3-3zeta
- Mus musculus
- Ywhab
- Rattus norvegicus
- Ywhab
- Saccharomyces cerevisiae
- BMH1
- Saccharomyces cerevisiae
- BMH2
In other databases
- GenAge model organism genes
External links
- OMIM
- 601289
- Ensembl
- ENSG00000166913
- Entrez Gene
- 7529
- UniGene
- 643544
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- YWHAB
- GeneCards
- YWHAB