GenAge entry for HESX1 (Homo sapiens)

Gene name (HAGRID: 184)

HGNC symbol
HESX1 
Aliases
RPX; ANF 
Common name
HESX homeobox 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description

HESX1 is an important regulator of development and, particularly, of pituitary development. It may antagonize the transcriptional activities of PROP1 [1726]. Mice without HESX1 develop pituitary dysplasia. Mutations in the human HESX1 gene have been associated with septooptic dysplasia [803]. As a member of the hypothalamus-pituitary system, HESX1 might, in theory, be involved in ageing even if it has so far not been directly associated with human ageing.

Cytogenetic information

Cytogenetic band
3p14.3
Location
57,197,916 bp to 57,200,252 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006351; transcription, DNA-templated
GO:0007420; brain development
GO:0030916; otic vesicle formation
GO:0043584; nose development
GO:0045892; negative regulation of transcription, DNA-templated
GO:0048853; forebrain morphogenesis
Cellular component: GO:0005634; nucleus
Function: GO:0003677; DNA binding
GO:0003682; chromatin binding
GO:0005515; protein binding
GO:0008022; protein C-terminus binding
GO:0043565; sequence-specific DNA binding
GO:0047485; protein N-terminus binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
STAT3, NCOR1
STRING interaction network
Protein-Protein network diagram for HESX1

Retrieve sequences for HESX1

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
hesx1
Mus musculus
Hesx1
Rattus norvegicus
Hesx1

Selected references

External links

EPD
ORF Accession
NM_003865
CDS Accession
NP_003856
OMIM
601802
HPRD
03482
Ensembl
HESX1
UniProt/Swiss-Prot
HESX1_HUMAN
GeneCards
HESX1
Entrez Gene
8820
GenAtlas
HESX1
Internet
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