GenAge entry for PROP1 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 5)

HGNC symbol: PROP1
Aliases
Common name: PROP paired-like homeobox 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description: A transcription factor involved in hormonal regulation and development, PROP1 sits upstream of POU1F1 [355]. The Ames dwarf, a mouse strain mutant for PROP1, is remarkably long-lived with some evidence of delayed ageing [10]. On the other hand, PROP1 mutations in mice are strongly influenced by genetic background and can be lethal in some cases [1802]. Human mutations in PROP1 result in pituitary hormone deficiency, typically characterized by growth retardation. Although some individuals may be long-lived 0142, it is not known to what extent and in what direction PROP1 mutations affect the human ageing process [1345].

Cytogenetic information

Cytogenetic band: 5q35.3
Location: 177,992,235 bp to 177,996,242 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001568; blood vessel development
GO:0006366; transcription from RNA polymerase II promoter
GO:0007417; central nervous system development
GO:0009953; dorsal/ventral pattern formation
GO:0016477; cell migration
GO:0021979; hypothalamus cell differentiation
GO:0043066; negative regulation of apoptotic process
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0048850; hypophysis morphogenesis
GO:0060070; canonical Wnt signaling pathway

And 2 more GO terms

Cellular component:

GO:0005634; nucleus
GO:0005667; transcription factor complex

Function:

GO:0000980; RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001205; transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0001206; transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0003682; chromatin binding
GO:0005515; protein binding
GO:0008013; beta-catenin binding
GO:0008022; protein C-terminus binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: CTNNB1
STRING interaction network

Retrieve sequences for PROP1

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: unc-42
Drosophila melanogaster: CG32532
Mus musculus: Prop1
Rattus norvegicus: Prop1

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Prop1

GenDR gene manipulations

A homolog of this gene for Mus musculus is present as Prop1