Caenorhabditis elegansGenAge entry for rbr-2 (Caenorhabditis elegans)

Gene information (ID: 976)

Symbol
rbr-2
Name
RB (Retinoblastoma Binding protein) Related
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Previously, the rbr-2(tm1231) strain has been reported to display reduced longevity, and overexpression of rbr-2 can extend lifespan of adult wild-type animals at 20 degrees (Greer et al., 2010). In contrast, the ok2544 rbr-2 mutation exhibits longer mean and maximum lifespan, both at 20 (~14%) and 25 (~15%) degrees.
% change in avg or median lifespan
Mean lifespan is approximately 15% higher.
Lifespan Effect
Increase
Genetic Manipulation
Mutation
Longevity Category
Anti-Longevity
Primary reference
    Observations
    RNA inteference of rbr-2 results in an incrased lifespan of up to 37%, depending on temperature.
    % change in avg or median lifespan
    Mean lifespan is 37% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    RNA interference
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      25% mean lifespan decrease
      % change in avg or median lifespan
      Average lifespan is 25% lower.
      Lifespan Effect
      Decrease
      Genetic Manipulation
      Mutations
      Longevity Category
      Pro-Longevity
      Primary reference

        In other databases

        GenAge microarray genes
        • A homolog of this gene for Homo sapiens is present as KDM5B
        CellAge
        • A homolog of this gene for Homo sapiens is present as KDM5B

        Homologs in other organisms

        Danio rerio
        KDM5A
        Danio rerio
        kdm5c
        Danio rerio
        kdm5bb
        Danio rerio
        kdm5ba
        Drosophila melanogaster
        lid
        Homo sapiens
        KDM5B
        Homo sapiens
        KDM5A
        Homo sapiens
        KDM5C
        Homo sapiens
        KDM5D
        Mus musculus
        Kdm5a
        Mus musculus
        Kdm5b
        Mus musculus
        Kdm5c
        Mus musculus
        Kdm5d
        Rattus norvegicus
        Kdm5b
        Rattus norvegicus
        Kdm5d
        Rattus norvegicus
        Kdm5c
        Rattus norvegicus
        Kdm5a
        Saccharomyces cerevisiae
        JHD2
        Schizosaccharomyces pombe
        msc1

        External links

        WormBase
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        Ensembl
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        Entrez Gene
        View on Entrez Gene database (177985)
        Homologues
        Search HomoloGene
        UniProt
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        Internet
        Search Google or Search Google Scholar