Cell Senescence Entries for KDM5B

Cell Types
Colon cancer
Cell Lines
HCT116, DLD1, Colo201
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Depletion of JARID1B (KDM5B) resulted in loss of epithelial differentiation and suppressed CRC cell growth, which is associated with induction of phosphorylation by the c-Jun N-terminal kinase (Jnk/Sapk) and SA-beta-galactosidase activity.
Primary Reference

    KDM5B Gene Information

    HGNC symbol
    KDM5B 
    Aliases
    CT31; PLU1; PUT1; PLU-1; JARID1B; PPP1R98; RBP2-H1; RBBP2H1A 
    Common name
    lysine demethylase 5B 
    Entrez Id
    10765
    Description
    This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]

    KDM5B Ontologies

    Gene Ontology
    Process: GO:60444; branching involved in mammary gland duct morphogenesis
    GO:44344; cellular response to fibroblast growth factor stimulus
    GO:34720; histone H3-K4 demethylation
    GO:34721; histone H3-K4 demethylation, trimethyl-H3-K4-specific
    GO:70306; lens fiber cell differentiation
    GO:60763; mammary duct terminal end bud growth
    GO:45892; negative regulation of transcription, DNA-templated
    GO:55114; oxidation-reduction process
    GO:10628; positive regulation of gene expression
    GO:33601; positive regulation of mammary gland epithelial cell proliferation
    GO:9791; post-embryonic development
    And 8 more GO terms
    Cellular component: GO:5829; cytosol
    GO:5654; nucleoplasm
    GO:5634; nucleus
    Function: GO:3677; DNA binding
    GO:32452; histone demethylase activity
    GO:32453; histone demethylase activity (H3-K4 specific)
    GO:34648; histone demethylase activity (H3-dimethyl-K4 specific)
    GO:34647; histone demethylase activity (H3-trimethyl-K4 specific)
    GO:16706; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
    GO:5515; protein binding
    GO:1990837; sequence-specific double-stranded DNA binding
    GO:3714; transcription corepressor activity
    GO:3700; transcription factor activity, sequence-specific DNA binding
    GO:8270; zinc ion binding
    And 1 more GO terms
    Show all GO terms

    Homologs of KDM5B in Model Organisms

    Danio rerio
    kdm5bb
    Mus musculus
    Kdm5b
    Rattus norvegicus
    Kdm5b
    Saccharomyces cerevisiae
    ECM5

    External links

    OMIM
    605393
    Ensembl
    ENSG00000117139
    Entrez Gene
    10765
    UniGene
    18891
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    KDM5B
    GeneCards
    KDM5B