GenAge entry for pash-1 (Caenorhabditis elegans)
Gene information (ID: 1936)
- Symbol
- pash-1
- Name
- PArtner of DroSHa (DRSH-1 interactor)
- Organism
- Caenorhabditis elegans (AnAge)
Potential relevance to longevity and/or ageing
- Observations
- At 25 degrees PASH-1 mutants display a reduced lifespan (mean 31% lower). This effect is not seen at 15 degrees. The pash-1 mutation is responsible for a defective miRNA biogenesis, and miRNA sysnthesis is required for both normal lifespan and for several lifespan extension mutants (eat-2, glp-1 and cyc1).
- % change in avg or median lifespan
- Median lifespan is 31% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Mutation
- Longevity Category
- Pro-Longevity
- Primary reference
-
In other databases
- CellAge
- A homolog of this gene for Homo sapiens is present as DGCR8
Homologs in other organisms
- Danio rerio
- dgcr8
- Drosophila melanogaster
- pasha
- Homo sapiens
- DGCR8
- Mus musculus
- Dgcr8
- Rattus norvegicus
- Dgcr8
External links
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (172950)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar