GenAge entry for PNC1 (Saccharomyces cerevisiae)
Gene information (ID: 1015)
- Symbol
- PNC1
- Name
- Pyrazinamidase and NiCotinamidase
- Organism
- Saccharomyces cerevisiae (AnAge)
Potential relevance to longevity and/or ageing
- Observations
- Increased expression of PNC1 is both necessary and sufficient for replicative lifespan extension by calorie restriction and low-intensity stress. under non-stressing conditions (2% glucose, 30C), a strain with additional copies of PNC1 (5XPNC1) had 70% longer replicative lifespan than the wild type and some cells lived for more than 70 divisions.Neither calorie restriction nor heat stress further increased the lifespan of the 5XPNC1 strain.
- % change in avg or median lifespan
- Replicative lifespan is 70% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- PNC1 overexpression suppresses the inhibitory effect of exogenously added NAM on silencing, life span, and Hst1-mediated transcriptional repression.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Chronological lifespan decreased
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Deletion
- Longevity Category
- Pro-Longevity
- Primary reference
-
In other databases
- GenAge model organism genes
- GenDR gene manipulations
Homologs in other organisms
- Caenorhabditis elegans
- pnc-2
- Caenorhabditis elegans
- pnc-1
- Drosophila melanogaster
- Naam
- Schizosaccharomyces pombe
- pnc1
External links
- Saccharomyces Genome Database
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (852846)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar