Caenorhabditis elegansGenAge entry for pnc-1 (Caenorhabditis elegans)

Gene information (ID: 741)

Symbol
pnc-1
Name
Pyrazinamidase and NiCotinamidase
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Nicotinamidase

Potential relevance to longevity and/or ageing

Observations
Knockouts showed a 30% decrease in maximum lifespan. Overexpression of pnc-1 increased adult survival under oxidative stress but did not extend the lifespan.
% change in max lifespan
Maximum lifespan is 30% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Knockout
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenDR gene manipulations
    • This gene is present as pnc-1

    Homologs in other organisms

    Schizosaccharomyces pombe
    pnc1

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (176833)
    Homologues
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    UniProt
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    Internet
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