Mus musculusGenAge entry for Trp53 (Mus musculus)

Gene information (ID: 682)

Symbol
Trp53
Aliases
bbl; bfy; bhy; p44; p53; Tp53
Name
Transformation related protein 53
Organism
Mus musculus (AnAge)
Known functions and activities
Tumour supressor involved in cell cycle regulation, apoptosis, and DNA repair

Potential relevance to longevity and/or ageing

Observations
Contrary to p53-null mice, mice with a p53 mutation (Ser18), affecting the substrate site for ATM and ATM-related (ATR) protein kinases, do not display an increased mortality due to early-onset tumors. Survival is however compromised, though not as severely as in the case of p53-null mice, and they still spontaneously develop late-onset tumors. Mutants live significantly shorter compared with wild-type mice (up to 23% less).
% change in avg or median lifespan
Median lifespan is up to 23% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Mutation
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Mutant mice with activated Trp53 display enhanced resistance to spontaneous tumours and signs of premature ageing including reduced lifespan, osteoporosis, organ atrophy and a diminished stress tolerance.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    Mutation
    Longevity Category
    Pro-Longevity
    Primary reference
      Observations
      super p53' mice do not show any indication of premature aging, Mice carrying p53-tg alleles in addition to the two endogenous alleles, exhibit an enhanced response to DNA damage and are significantly protected from cancer when compared with normal mice. This is probably reflecting the fact that p53 is under normal regulatory control.
      Lifespan Effect
      Not Recorded
      Genetic Manipulation
      Overexpression
      Primary reference
        Observations
        Haploid loss of p53 overcame embryonic senescence but failed to prevent the adult mutant mice from prematurely aging, which included decreased life span, reduced body fat deposition, osteoporosis, skin atrophy, and decreased wound healing.
        Lifespan Effect
        Decrease
        Genetic Manipulation
        Deletion
        Longevity Category
        Pro-Longevity
        Primary reference
          Observations
          Overexpression of p44 upsets the balance that normally exists between the full-length and short forms of p53 and leads to a phenotype of growth suppression and premature aging in mice (40% reduction in MLS). Growth suppression by p44 links small size, proliferation deficits, cellular senescence, and organismal aging to abnormal IGF signaling in the mouse.
          % change in max lifespan
          Maximum lifespan is 40% lower.
          Lifespan Effect
          Decrease
          Genetic Manipulation
          Overexpression of the short isoform of p53 (p44)
          Primary reference
            Observations
            Mice lacking both p27 and p53 exhibit a decreased lifespan and develop unique tumors, including papillary carcinoma of the colon, hemangiosarcoma, and leiomyosarcoma.
            Lifespan Effect
            Decrease
            Genetic Manipulation
            Deletion
            Longevity Category
            Pro-Longevity
            Primary reference

              In other databases

              GenAge human genes
              • A homolog of this gene for Homo sapiens is present as TP53
              LongevityMap
              • A homolog of this gene for Homo sapiens is present as TP53
              CellAge
              • A homolog of this gene for Homo sapiens is present as TP53

              Homologs in other organisms

              Danio rerio
              tp53
              Homo sapiens
              TP53
              Rattus norvegicus
              Tp53

              External links

              Mouse Genome Informatics
              Search
              Ensembl
              Search
              Entrez Gene
              View on Entrez Gene database (22059)
              Homologues
              Search HomoloGene
              UniProt
              Search
              Internet
              Search Google or Search Google Scholar