Cell Senescence Entries for TP53

Cell Types
Bladder cancer
Cell Lines
EJ
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Stress-induced, Replicative
Senescence Effect
Promotes
Observations
Overexpression of wild type p53 (TP53) in EJ cells (which have lost functional p53) triggered rapid growth arrest with senescence features. Growth arrest in response to p53 induction was irreversible within 48-72 hrs. 95% of EJ-p53 cells showed high levels of SA-beta-galactosidase staining. The cells also showed the flattened, enlarged cell morphology commonly observed in senescent fibroblasts.
Primary Reference

    TP53 Gene Information

    HGNC symbol
    TP53 
    Aliases
    P53; BCC7; LFS1; TRP53 
    Common name
    tumor protein p53 
    Entrez Id
    7157
    Description
    This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

    TP53 Ontologies

    Gene Ontology
    Process: GO:30330; DNA damage response, signal transduction by p53 class mediator
    GO:6977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
    GO:6978; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
    GO:733; DNA strand renaturation
    GO:6983; ER overload response
    GO:7265; Ras protein signal transduction
    GO:6914; autophagy
    GO:6284; base-excision repair
    GO:7569; cell aging
    GO:7050; cell cycle arrest
    GO:30154; cell differentiation
    And 66 more GO terms
    Cellular component: GO:16605; PML body
    GO:5737; cytoplasm
    GO:5829; cytosol
    GO:5783; endoplasmic reticulum
    GO:5622; intracellular
    GO:5759; mitochondrial matrix
    GO:5739; mitochondrion
    GO:16604; nuclear body
    GO:790; nuclear chromatin
    GO:16363; nuclear matrix
    GO:5730; nucleolus
    And 6 more GO terms
    Function: GO:5524; ATP binding
    GO:3677; DNA binding
    GO:977; RNA polymerase II regulatory region sequence-specific DNA binding
    GO:981; RNA polymerase II transcription factor activity, sequence-specific DNA binding
    GO:1085; RNA polymerase II transcription factor binding
    GO:51087; chaperone binding
    GO:3682; chromatin binding
    GO:5507; copper ion binding
    GO:1046; core promoter sequence-specific DNA binding
    GO:3684; damaged DNA binding
    GO:97718; disordered domain specific binding
    And 23 more GO terms
    Show all GO terms

    Homologs of TP53 in Model Organisms

    Danio rerio
    tp53
    Mus musculus
    Tp53
    Rattus norvegicus
    Tp53

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Mus musculus is present as Trp53
    GenAge human genes
    • This gene is present as TP53
    LongevityMap
    • This gene is present as TP53

    External links

    OMIM
    191170
    Ensembl
    ENSG00000141510
    Entrez Gene
    7157
    UniGene
    437460
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    TP53
    GeneCards
    TP53