- Symbol
- Shc1
- Aliases
- Shc; p66; ShcA; p66shc
- Name
- SHC (Src homology 2 domain containing) transforming protein 1
- Organism
- Mus musculus (AnAge)
- Known functions and activities
- Regulation of intra-cellular redox levels, signal transduction, and apoptosis
- Observations
- In contrast to a previous study (Migliaccio et al., 1999), knockout of Shc1 was not found to increase median or maximum life span in mice.
- Lifespan Effect
- No Change
- Genetic Manipulation
- Knockout
- Primary reference
-
- Observations
- Knockout mice had a 30% increase in lifespan.
- % change in avg or median lifespan
- Lifespan is 30% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Knockout
- Longevity Category
- Anti-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as shc-1
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as SHC1
- LongevityMap
- A homolog of this gene for Homo sapiens is present as SHC1
- Caenorhabditis elegans
- shc-1
- Danio rerio
- shc1
- Drosophila melanogaster
- Shc
- Homo sapiens
- SHC1
- Rattus norvegicus
- Shc1
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (20416)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Shc1 (Mus musculus)