Saccharomyces cerevisiaeGenAge entry for ASF1 (Saccharomyces cerevisiae)

Gene information (ID: 1699)

Symbol
ASF1
Aliases
CIA1
Name
Anti-Silencing Function
Organism
Saccharomyces cerevisiae (AnAge)

Potential relevance to longevity and/or ageing

Observations
Yeast lacking Asf1 are short lived, having a median replicative life span of about 7 generations in comparison to the median life span of about 27 generations for wild-type yeast in multiple yeast backgrounds. Asf1 mutants also exhibit some phenotypes characteristic of aging.
% change in avg or median lifespan
Replicative lifespan is about 74% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Deletion
Longevity Category
Necessary for fitness
Primary reference
    Observations
    Replicative lifespan decreased by 65% in the alpha strain
    % change in avg or median lifespan
    Replicative lifespan is 65% lower.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    Deletion
    Longevity Category
    Necessary for fitness
    Primary reference

      Homologs in other organisms

      Caenorhabditis elegans
      asf-1
      Danio rerio
      asf1ba
      Drosophila melanogaster
      asf1
      Homo sapiens
      ASF1B
      Mus musculus
      Asf1b
      Rattus norvegicus
      Asf1b
      Schizosaccharomyces pombe
      cia1

      External links

      Saccharomyces Genome Database
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (853327)
      Homologues
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      UniProt
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      Internet
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