Cell Senescence Entries for ASF1A

Cell Types
Lung fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockout, Overexpression
Type of senescence
Replicative, Oncogene-induced
Senescence Effect
Promotes
Observations
Ectopic expression of ASF1A in primary human fibroblasts caused cells to assume markers of senescence, including a large flat morphology, increased SA-beta-galactosidase activity and formation of SA-heterochromatin foci. In contrast, knockdown of ASF1A decreased the number of cells containing SA-heterochromatin foci and increased the BrdU-positive cells in Ras-induced senescence.
Primary Reference

    ASF1A Gene Information

    HGNC symbol
    ASF1A 
    Aliases
    CIA; CGI-98; HSPC146 
    Common name
    anti-silencing function 1A histone chaperone 
    Entrez Id
    25842
    Description
    This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair. [provided by RefSeq, Jul 2008]

    ASF1A Ontologies

    Gene Ontology
    Process: GO:6281; DNA repair
    GO:6335; DNA replication-dependent nucleosome assembly
    GO:6336; DNA replication-independent nucleosome assembly
    GO:16569; covalent chromatin modification
    GO:42692; muscle cell differentiation
    GO:31936; negative regulation of chromatin silencing
    GO:6334; nucleosome assembly
    GO:1649; osteoblast differentiation
    GO:6351; transcription, DNA-templated
    Cellular component: GO:790; nuclear chromatin
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:43234; protein complex
    Function: GO:3682; chromatin binding
    GO:42393; histone binding
    GO:5515; protein binding
    Show all GO terms

    Homologs of ASF1A in Model Organisms

    Mus musculus
    Asf1a
    Rattus norvegicus
    Asf1a

    External links

    OMIM
    609189
    Ensembl
    ENSG00000111875
    Entrez Gene
    25842
    UniGene
    292316
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    ASF1A
    GeneCards
    ASF1A