LongevityMap variant

Entry Details

Longevity Association: Significant
Population: Dutch
Study Design: Associations between variation in SNPs in the SIRT1 gene and human survival were investigated in 1,390 subjects from a general population-based cohort with 18 years of follow-up
Conclusions: Carriers of the minor allele of rs12778366 had better glucose tolerance and had a significantly reduced mortality risk compared to the wild types (HR = 0.69).

HGNC symbol: SIRT1
Aliases: SIR2; SIR2L1; SIR2alpha
Common name: sirtuin 1
Description: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Other longevity studies of this gene: 33
OMIM: 604479
Ensembl: ENSG00000096717
UniProt/Swiss-Prot: A0A024QZQ1_HUMAN
Entrez Gene: 23411
UniGene: 369779
HapMap: View on HapMap

GenAge model organism genes

GenAge human genes

GenDR gene manipulations

CellAge

Figarska et al. (2013)