GenDR Dietary Restriction Gene Manipulation: sir-2.1
Gene Information (Entrez Gene ID: 177924)
- Symbol
- sir-2.1
- Name
- Yeast SIR related 1
- Organism
- Caenorhabditis elegans (AnAge)
- Entrez Gene ID
- 177924
Potential relevance to dietary restriction and ageing
- Observations
-
sir-2.1 deletion slightly reduces lifespan of wild-type [2296]. sir-2.1 overexpression extends lifespan by about 50% and this lifespan extension depends on DAF-16 activity and it does not synergize with daf-2 [199]. sir-2.1 suppresses longevity of eat-2 mutants, but not daf-2 mutants. sir-2.1 is therefore partially required for lifespan extension from mutation of eat-2 [2296], but is completely independent for lifespan extension from DR using a reduced feeding protocol [3446]. Solid DR increases lifespan of wild-type and sir-2.1 mutants to the same extent [2568].
- References
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In other databases
- GenAge model organism genes
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as SIRT1
- GenDR gene manipulations
- LongevityMap
- A homolog of this gene for Homo sapiens is present as SIRT1
- CellAge
- A homolog of this gene for Homo sapiens is present as SIRT1
Homologs
- Danio rerio
- sirt1
- Drosophila melanogaster
- Sir2
- Homo sapiens
- SIRT1
- Mus musculus
- Sirt1
- Rattus norvegicus
- Sirt1
- Saccharomyces cerevisiae
- HST1
- Saccharomyces cerevisiae
- SIR2
- Schizosaccharomyces pombe
- hst2
External links
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- ID 177924
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar