LongevityMap variant
Entry Details
- Longevity Association
- Non-significant
- Population
- Danish, German, Dutch
- Study Design
- 102 SNPs from 16 longevity candidate genes were examined in Danish. 1089 individuals (ages 92.2-93.8, mean age 93.2, 71.3 female) and 736 middle-aged controls (46-55 y, mean age 50.6, 49.6% female) were involved in this case-control study. Then the results were replicated in a German cohort of 1613 individuals (95-110 y, 73.2% female) and 1104 middle-aged controls (mean age 67.2, SD 4.07, 74.3% female). A 11 years study was introduced in Danish cohort to identify the SNPs associated with longevity, then the results were verified in Dutch longitudinal cohort.
- Conclusions
- After correcting for multiple testing, no SNPs were significantly associated with longevity, except in APOE and CETP. rs4343 (ACE) was nominally significantly associated with longevity (P < 0.05).
- Identifier
- rs12778366
- In Other Studies (IDs)
- 379 2249
- Cytogenetic Location
- 10q21.3
- UCSC Genome Browser
- View 10q21.3 on the UCSC genome browser
Gene details
- HGNC symbol
- SIRT1
- Aliases
- SIR2; SIR2L1; SIR2alpha
- Common name
- sirtuin 1
- Description
- This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
- Other longevity studies of this gene
- 33
- OMIM
- 604479
- Ensembl
- ENSG00000096717
- UniProt/Swiss-Prot
- A0A024QZQ1_HUMAN
- Entrez Gene
- 23411
- UniGene
- 369779
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- sir-2.1
- Danio rerio
- sirt1
- Drosophila melanogaster
- Sir2
- Mus musculus
- Sirt1
- Rattus norvegicus
- Sirt1
- Saccharomyces cerevisiae
- HST1
- Saccharomyces cerevisiae
- SIR2
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as sir-2.1
- A homolog of this gene for Drosophila melanogaster is present as Sir2
- A homolog of this gene for Saccharomyces cerevisiae is present as SIR2
- A homolog of this gene for Mus musculus is present as Sirt1
- A homolog of this gene for Saccharomyces cerevisiae is present as HST1
- GenAge human genes
- This gene is present as SIRT1
- GenDR gene manipulations
- A homolog of this gene for Drosophila melanogaster is present as Sir2
- A homolog of this gene for Mus musculus is present as Sirt1
- A homolog of this gene for Caenorhabditis elegans is present as sir-2.1
- A homolog of this gene for Saccharomyces cerevisiae is present as SIR2
- A homolog of this gene for Saccharomyces cerevisiae is present as HST1
- CellAge
- This gene is present as SIRT1