Cell Senescence Entries for SIRT1
- Cell Types
- Lung fibroblast
- Cell Lines
- 2BS
- Cancer Cell?
- No
- Method
- Overexpression
- Type of senescence
- Replicative
- Senescence Effect
- Inhibits
- Observations
- Overexpression of SIRT1 promoted cell proliferation and antagonized cellular senescence with characteristic features of delayed senescence, including reduced SA-beta-galactosidase staining, reduced SA-heterochromatin foci formation and G1 phase arrest, increased cell growth rate and extended cellular lifespan in human fibroblasts.
- Primary Reference
SIRT1 Gene Information
- HGNC symbol
- SIRT1
- Aliases
- SIR2; SIR2L1; SIR2alpha
- Common name
- sirtuin 1
- Entrez Id
- 23411
- Description
- This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
SIRT1 Ontologies
- Gene Ontology
-
Process: GO:6281; DNA repair
GO:6260; DNA replication
GO:731; DNA synthesis involved in DNA repair
GO:70914; UV-damage excision repair
GO:1525; angiogenesis
GO:42595; behavioral response to starvation
GO:7569; cell aging
GO:1678; cellular glucose homeostasis
GO:6974; cellular response to DNA damage stimulus
GO:70301; cellular response to hydrogen peroxide
GO:71456; cellular response to hypoxia
And 106 more GO terms Cellular component: GO:35098; ESC/E(Z) complex
GO:16605; PML body
GO:5677; chromatin silencing complex
GO:5737; cytoplasm
GO:5829; cytosol
GO:5739; mitochondrion
GO:790; nuclear chromatin
GO:5635; nuclear envelope
GO:5719; nuclear euchromatin
GO:5720; nuclear heterochromatin
GO:5637; nuclear inner membrane
And 5 more GO terms Function: GO:43398; HLH domain binding
GO:3950; NAD+ ADP-ribosyltransferase activity
GO:70403; NAD+ binding
GO:17136; NAD-dependent histone deacetylase activity
GO:46969; NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:34979; NAD-dependent protein deacetylase activity
GO:43425; bHLH transcription factor binding
GO:1046; core promoter sequence-specific DNA binding
GO:19213; deacetylase activity
GO:19899; enzyme binding
GO:42393; histone binding
And 14 more GO terms
Homologs of SIRT1 in Model Organisms
- Caenorhabditis elegans
- sir-2.1
- Danio rerio
- sirt1
- Drosophila melanogaster
- Sir2
- Mus musculus
- Sirt1
- Rattus norvegicus
- Sirt1
- Saccharomyces cerevisiae
- HST1
- Saccharomyces cerevisiae
- SIR2
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as sir-2.1
- A homolog of this gene for Drosophila melanogaster is present as Sir2
- A homolog of this gene for Saccharomyces cerevisiae is present as SIR2
- A homolog of this gene for Mus musculus is present as Sirt1
- A homolog of this gene for Saccharomyces cerevisiae is present as HST1
- GenAge human genes
- This gene is present as SIRT1
- GenDR gene manipulations
- A homolog of this gene for Drosophila melanogaster is present as Sir2
- A homolog of this gene for Mus musculus is present as Sirt1
- A homolog of this gene for Caenorhabditis elegans is present as sir-2.1
- A homolog of this gene for Saccharomyces cerevisiae is present as SIR2
- A homolog of this gene for Saccharomyces cerevisiae is present as HST1
- LongevityMap
- This gene is present as SIRT1
External links
- OMIM
- 604479
- Ensembl
- ENSG00000096717
- Entrez Gene
- 23411
- UniGene
- 369779
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- SIRT1
- GeneCards
- SIRT1