Cell Senescence Entries for SIRT1

Cell Types
Lung fibroblast
Cell Lines
2BS
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Overexpression of SIRT1 promoted cell proliferation and antagonized cellular senescence with characteristic features of delayed senescence, including reduced SA-beta-galactosidase staining, reduced SA-heterochromatin foci formation and G1 phase arrest, increased cell growth rate and extended cellular lifespan in human fibroblasts.
Primary Reference

    SIRT1 Gene Information

    HGNC symbol
    SIRT1 
    Aliases
    SIR2; SIR2L1; SIR2alpha 
    Common name
    sirtuin 1 
    Entrez Id
    23411
    Description
    This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

    SIRT1 Ontologies

    Gene Ontology
    Process: GO:6281; DNA repair
    GO:6260; DNA replication
    GO:731; DNA synthesis involved in DNA repair
    GO:70914; UV-damage excision repair
    GO:1525; angiogenesis
    GO:42595; behavioral response to starvation
    GO:7569; cell aging
    GO:1678; cellular glucose homeostasis
    GO:6974; cellular response to DNA damage stimulus
    GO:70301; cellular response to hydrogen peroxide
    GO:71456; cellular response to hypoxia
    And 106 more GO terms
    Cellular component: GO:35098; ESC/E(Z) complex
    GO:16605; PML body
    GO:5677; chromatin silencing complex
    GO:5737; cytoplasm
    GO:5829; cytosol
    GO:5739; mitochondrion
    GO:790; nuclear chromatin
    GO:5635; nuclear envelope
    GO:5719; nuclear euchromatin
    GO:5720; nuclear heterochromatin
    GO:5637; nuclear inner membrane
    And 5 more GO terms
    Function: GO:43398; HLH domain binding
    GO:3950; NAD+ ADP-ribosyltransferase activity
    GO:70403; NAD+ binding
    GO:17136; NAD-dependent histone deacetylase activity
    GO:46969; NAD-dependent histone deacetylase activity (H3-K9 specific)
    GO:34979; NAD-dependent protein deacetylase activity
    GO:43425; bHLH transcription factor binding
    GO:1046; core promoter sequence-specific DNA binding
    GO:19213; deacetylase activity
    GO:19899; enzyme binding
    GO:42393; histone binding
    And 14 more GO terms
    Show all GO terms

    Homologs of SIRT1 in Model Organisms

    Caenorhabditis elegans
    sir-2.1
    Danio rerio
    sirt1
    Drosophila melanogaster
    Sir2
    Mus musculus
    Sirt1
    Rattus norvegicus
    Sirt1
    Saccharomyces cerevisiae
    HST1
    Saccharomyces cerevisiae
    SIR2

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as sir-2.1
    • A homolog of this gene for Drosophila melanogaster is present as Sir2
    • A homolog of this gene for Saccharomyces cerevisiae is present as SIR2
    • A homolog of this gene for Mus musculus is present as Sirt1
    • A homolog of this gene for Saccharomyces cerevisiae is present as HST1
    GenAge human genes
    • This gene is present as SIRT1
    GenDR gene manipulations
    • A homolog of this gene for Drosophila melanogaster is present as Sir2
    • A homolog of this gene for Mus musculus is present as Sirt1
    • A homolog of this gene for Caenorhabditis elegans is present as sir-2.1
    • A homolog of this gene for Saccharomyces cerevisiae is present as SIR2
    • A homolog of this gene for Saccharomyces cerevisiae is present as HST1
    LongevityMap
    • This gene is present as SIRT1

    External links

    OMIM
    604479
    Ensembl
    ENSG00000096717
    Entrez Gene
    23411
    UniGene
    369779
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    SIRT1
    GeneCards
    SIRT1